Patents Assigned to Simcha IL-18, Inc.
  • Interleukin-18 variants and methods of use
    Patent number: 11850276
    Abstract: The present disclosure provides compositions and methods comprising stabilized IL-18 polypeptides for use in therapeutic and non-therapeutic applications. In some cases, the stabilized IL-18 proteins provide IL-18 signaling activity even in the presence of an inhibitory molecule such as IL-18BP. Also provide are methods of administration and methods for making active polypeptides.
    Type: Grant
    Filed: December 1, 2022
    Date of Patent: December 26, 2023
    Assignees: Simcha IL-18, Inc., Yale University
    Inventors: Aaron Ring, Tom Boone