Patents Assigned to Simes S.p.A.
  • Patent number: 10895355
    Abstract: An assembly for realising a lamp incorporated into a masonry wall, comprises a lamp housing that delimits a lamp seat suitable to house a lamp body, and a mould suitable to be removably fixed to the lamp housing and to the inner side of a formwork in which the pouring is carried out, so as to realise, after pouring cement in the formwork, a light-emission cavity open on the outer surface of the masonry wall. The mould is suitable to rigidly support the lamp housing before and during the pouring of the cement and is provided with mould fastening means suitable to removably fix the mould to the inner side of the formwork.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: January 19, 2021
    Assignee: SIMES S.p.A.
    Inventor: Roberto Botti
  • Patent number: 4683245
    Abstract: This invention relates to a process for the separation of moprolol into its two optical antipodes, substantially characterized by the fact of salifying racemic moprolol with L(+)glutamic acid; treating the thus obtained mixture of diastereoisomeric salts with a water/alcohol mixture, in this way separating the L(+)glutamate insoluble salt of (+)moprolol; treating the resultant mother liquors which contain in solution the L(+)glutamate salt of (-)moprolol with a base so as to separate the laevorotatory isomer of crystalline moprolol, which finally undergoes a purification. The invention also relates to a pharmaceutical composition containing said laevorotatoryisomer of moprolol.
    Type: Grant
    Filed: October 14, 1982
    Date of Patent: July 28, 1987
    Assignee: SIMES S.p.A. Societa Italiana Medicinali e Sintetici
    Inventors: Giorgio Ferrari, Vittorio Vecchietti
  • Patent number: 4644004
    Abstract: Pyridinecarboxylic esters of dopamine and of its N-alkyl derivatives, salts thereof with pharmaceutically acceptable organic or inorganic acids, process for preparing them and pharmaceutical compositions containing them which are particularly useful in the treatment of cardiovascular and renal disorders.
    Type: Grant
    Filed: February 8, 1985
    Date of Patent: February 17, 1987
    Assignee: Simes S.p.A.
    Inventors: Cesare Casagrande, Emilio Mussini, Vittorio Vecchietti
  • Patent number: 4467094
    Abstract: New derivatives of 1,2-ethylenediamine and salts thereof endowed with vascular antispasmodic and antiallergic activity; processes for preparing them, some new intermediates useful in their preparation and pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 3, 1982
    Date of Patent: August 21, 1984
    Assignee: Simes S.p.A.
    Inventors: Cesare Casagrande, Giorgio Ferrari
  • Patent number: 4381305
    Abstract: New derivatives of 1,2-ethylenediamine and salts thereof endowed with vascular antispasmodic and antiallergic activity; processes for preparing them, some new intermediates useful in their preparation and pharmaceutical compositions containing them.
    Type: Grant
    Filed: June 5, 1981
    Date of Patent: April 26, 1983
    Assignee: Simes S.p.A.
    Inventors: Cesare Casagrande, Giorgio Ferrari
  • Patent number: 4376117
    Abstract: The magnesium salt of creatinol-O-phosphate, having the formula: ##STR1## is useful in the treatment and in the prevention of the myocardiac infarction.The preparation of the above magnesium salt takes place by reacting creatinol-O-phosphate, as a water solution, with a reactive magnesium compound.The magnesium salt according to the invention may be obtained in either anhydrous or hydrated form and is useful for the preparation of the normal pharmaceutical formulations for the administration by oral and parenteral route.
    Type: Grant
    Filed: October 17, 1980
    Date of Patent: March 8, 1983
    Assignee: Simes S.p.A.
    Inventors: Theophile Godfraind, Paolo Ghirardi, Giorgio Ferrari, Cesare Casagrande
  • Patent number: 4362721
    Abstract: There are disclosed penicillanic and cephalosporanic derivatives of the formula: ##STR1## wherein R is H or --OH; R.sub.1 is a carbohydrate hexose radical of 3-O-glucose, 6-O-galactose, 3-O-glucose acetals, 3-O-glucose ketals, 6-O-galactose acetals, and 6-O-galactose ketals, and R.sub.2 is: ##STR2## where R.sub.3 is H or an alkali or alkaline-earth metal. The preparation of the derivatives and pharmaceutical compositions containing same are also disclosed.A process according to the invention comprises reacting a compound of the formula ##STR3## with a hexose carbohydrate, in --OH protected form, in an aqueous medium, in the presence of a water-miscible organic solvent, in the presence of a base, the reaction product being optionally transformed into the derivative wherein R.sub.1 is a carbohydrate in the unprotected form by treatment with Lewis' acid or a hydrogen halide acid.
    Type: Grant
    Filed: December 3, 1981
    Date of Patent: December 7, 1982
    Assignee: Simes S.p.A.
    Inventors: Giorgio Ferrari, Vittorio Vecchietti
  • Patent number: 4287211
    Abstract: Novel derivatives of phenylethylamine, having general formula: ##STR1## wherein R is hydrogen or a lower alkyl, are disclosed, to be used in the therapy of diseases of the digestive apparatus, particularly gastric and/or duodenal ulcers. The novel derivatives of phenylethylamine are prepared(a) from a compound of formula (II) ##STR2## by reaction with potassium cyanate, in the presence of an organic acid; (b) from the compound of formula (II) which is converted to the corresponding phenylcarbonic derivative by reacting with phenylchloroformiate and then with ammonia(c) from a compound of formula (IV) ##STR3## which is converted to a compound of formula (V), the latter being converted to the desired derivatives (I) by treatment with aqueous alkali.
    Type: Grant
    Filed: December 28, 1979
    Date of Patent: September 1, 1981
    Assignee: Simes, S.p.A.
    Inventors: Giorgio Ferrari, Vittorio Vecchietti
  • Patent number: 4272529
    Abstract: The N-m-trifluoromethylphenylanthranilates of O-alcoxycarbonylphenyl, having the formula ##STR1## wherein R is an alkyl group, preferably comprising 1 to 4 carbon atoms, besides being of low toxicity, are endowed with anti-inflammatory properties and are adapted for the treatment of inflammatory and thrombotic diseases. The method for the preparation of the above compounds comprises reacting the N-m-trifluoromethylphenylisatoic anhydride with an alkyl salicylate.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: June 9, 1981
    Assignee: Simes S.p.A.
    Inventors: Cesare Casagrande, Giorgio Ferrari
  • Patent number: D827917
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: September 4, 2018
    Assignee: SIMES S.p.A.
    Inventor: Roberto Botti
  • Patent number: D827918
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: September 4, 2018
    Assignee: SIMES S.p.A.
    Inventor: Roberto Botti
  • Patent number: D828608
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: September 11, 2018
    Assignee: SIMES S.p.A.
    Inventor: Roberto Botti
  • Patent number: D829953
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: October 2, 2018
    Assignee: SIMES S.p.A.
    Inventor: Roberto Botti
  • Patent number: D913559
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: March 16, 2021
    Assignee: SIMES S.p.A.
    Inventor: Roberto Botti