Abstract: Pyridinecarboxylic esters of dopamine and of its N-alkyl derivatives, salts thereof with pharmaceutically acceptable organic or inorganic acids, process for preparing them and pharmaceutical compositions containing them which are particularly useful in the treatment of cardiovascular and renal disorders.
Abstract: New derivatives of 1,2-ethylenediamine and salts thereof endowed with vascular antispasmodic and antiallergic activity; processes for preparing them, some new intermediates useful in their preparation and pharmaceutical compositions containing them.
Abstract: New derivatives of 1,2-ethylenediamine and salts thereof endowed with vascular antispasmodic and antiallergic activity; processes for preparing them, some new intermediates useful in their preparation and pharmaceutical compositions containing them.
Abstract: The magnesium salt of creatinol-O-phosphate, having the formula: ##STR1## is useful in the treatment and in the prevention of the myocardiac infarction.The preparation of the above magnesium salt takes place by reacting creatinol-O-phosphate, as a water solution, with a reactive magnesium compound.The magnesium salt according to the invention may be obtained in either anhydrous or hydrated form and is useful for the preparation of the normal pharmaceutical formulations for the administration by oral and parenteral route.
Type:
Grant
Filed:
October 17, 1980
Date of Patent:
March 8, 1983
Assignee:
Simes S.p.A.
Inventors:
Theophile Godfraind, Paolo Ghirardi, Giorgio Ferrari, Cesare Casagrande
Abstract: There are disclosed penicillanic and cephalosporanic derivatives of the formula: ##STR1## wherein R is H or --OH; R.sub.1 is a carbohydrate hexose radical of 3-O-glucose, 6-O-galactose, 3-O-glucose acetals, 3-O-glucose ketals, 6-O-galactose acetals, and 6-O-galactose ketals, and R.sub.2 is: ##STR2## where R.sub.3 is H or an alkali or alkaline-earth metal. The preparation of the derivatives and pharmaceutical compositions containing same are also disclosed.A process according to the invention comprises reacting a compound of the formula ##STR3## with a hexose carbohydrate, in --OH protected form, in an aqueous medium, in the presence of a water-miscible organic solvent, in the presence of a base, the reaction product being optionally transformed into the derivative wherein R.sub.1 is a carbohydrate in the unprotected form by treatment with Lewis' acid or a hydrogen halide acid.
Abstract: Novel derivatives of phenylethylamine, having general formula: ##STR1## wherein R is hydrogen or a lower alkyl, are disclosed, to be used in the therapy of diseases of the digestive apparatus, particularly gastric and/or duodenal ulcers. The novel derivatives of phenylethylamine are prepared(a) from a compound of formula (II) ##STR2## by reaction with potassium cyanate, in the presence of an organic acid; (b) from the compound of formula (II) which is converted to the corresponding phenylcarbonic derivative by reacting with phenylchloroformiate and then with ammonia(c) from a compound of formula (IV) ##STR3## which is converted to a compound of formula (V), the latter being converted to the desired derivatives (I) by treatment with aqueous alkali.
Abstract: The N-m-trifluoromethylphenylanthranilates of O-alcoxycarbonylphenyl, having the formula ##STR1## wherein R is an alkyl group, preferably comprising 1 to 4 carbon atoms, besides being of low toxicity, are endowed with anti-inflammatory properties and are adapted for the treatment of inflammatory and thrombotic diseases. The method for the preparation of the above compounds comprises reacting the N-m-trifluoromethylphenylisatoic anhydride with an alkyl salicylate.