Patents Assigned to Singapore Health Services Pte, Ltd
  • Publication number: 20240190953
    Abstract: Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.
    Type: Application
    Filed: March 1, 2024
    Publication date: June 13, 2024
    Applicants: Singapore Health Services PTE LTD., National University of Singapore, Boehringer Ingelheim International GmbH
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • Publication number: 20240156913
    Abstract: Methods of treating and preventing metabolic disease through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
    Type: Application
    Filed: October 6, 2023
    Publication date: May 16, 2024
    Applicants: Singapore Health Services PTE LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer, Brijesh Kumar Singh, Anissa Widjaja
  • Publication number: 20240141004
    Abstract: Diagnosis, treatment and prophylaxis of diseases and conditions associated with smooth muscle cell (SMC) dysfunction are provided through the inhibition or IL-11-mediated signalling.
    Type: Application
    Filed: August 31, 2023
    Publication date: May 2, 2024
    Applicants: Singapore Health Services PTE LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer, Wei Wen Lim, Benjamin Wei Ming Ng
  • Patent number: 11954854
    Abstract: Disclosed is a method for training a neural network to quantify the vessel calibre of retina fundus images. The method involves receiving a plurality of fundus images; pre-processing the fundus images to normalise images features of the fundus images; and training a multi-layer neural network, the neural network comprising of a convolutional unit, multiple dense blocks alternating with transition units for down-sampling image features determined by the neural network, and a fully-connected unit, wherein each dense block comprises a series of cAdd units packed with multiple convolutions, and each transition layer comprises a convolution with pooling.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: April 9, 2024
    Assignees: National University of Singapore, Singapore Health Services Pte Ltd
    Inventors: Wynne Hsu, Mong Li Lee, Dejiang Xu, Tien Yin Wong, Yim Lui Cheung
  • Patent number: 11939374
    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: March 26, 2024
    Assignees: Singapore Health Services PTE LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer
  • Publication number: 20240024419
    Abstract: The invention relates to methods of increasing sensitivity of an epidermal growth factor receptor (EGFR)-related cancer to EGFR tyrosine kinase inhibitor (TKI) comprising administering a therapeutically effective amount of EGFR isoform D to a subject in need thereof. The invention also relates to methods of treating a subject suffering from an EGFR-related cancer comprising administering to the subject an effective amount of EGFR isoform D and a TKI. In one embodiment, the EGFR-related cancer is head and neck squamous cell carcinoma (HNSCC).
    Type: Application
    Filed: August 25, 2021
    Publication date: January 25, 2024
    Applicant: SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Fui Teen CHONG, Dorival MENDES RODRIGUES-JUNIOR, Narayanan Gopalakrishna IYER, Hui Sun LEONG, Daniel Shao-Wen TAN, Darren Shen Yon TOH
  • Publication number: 20230399393
    Abstract: The present disclosure relates to the diagnosis, treatment and prophylaxis of age-related diseases, and increasing healthspan. Provided are methods of treating or preventing an age-related disease/condition, and in particular of treating or preventing frailty, comprising administering a therapeutically or prophylactically effective amount of an agent capable of inhibiting interleukin 11 (IL-11)-mediated signalling to a subject. Also provided are agents capable of inhibiting interleukin 11 (IL-11)-mediated signalling for use in such a method. Further provided is the use of agents capable of inhibiting interleukin 11 (IL-11)-mediated signalling in the manufacture of a medicament for use in such a method.
    Type: Application
    Filed: October 29, 2021
    Publication date: December 14, 2023
    Applicants: National University of Singapore, Singapore Health Services PTE LTD.
    Inventors: Benjamin Corden, Anissa Widjaja, Sebastian Schaeffer, Stuart Cook, Brijesh Kumar Singh
  • Patent number: 11820821
    Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: November 21, 2023
    Assignees: SINGAPORE HEALTH SERVICES PTE LTD, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Hau Wan Leung, Andre Boon Hwa Choo, Mei Yee Vanessa Ding, Shao Weng Daniel Tan, Narayanan Gopalakrishna Iyer
  • Patent number: 11813311
    Abstract: Methods of treating and preventing metabolic disease through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: November 14, 2023
    Assignees: Singapore Health Services PTE LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer, Brijesh Kumar Singh, Anissa Widjaja
  • Patent number: 11802139
    Abstract: The present invention relates to compounds comprising formula I: Amino Acid Sequence-(L)n-DMARD wherein the amino acid sequence comprises QKRAAYDQYGHAAFE-NH2 (SEQ ID NO: 1), DMARD is a disease modifying antirheumatic agent L is a linker unit,—is a covalent bond and n is 0 or 1 and methods of using the compound for treatment of autoimmune diseases. In a preferred embodiment the DMARD is selected from Chloroquine and Hydroxychloroquine.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: October 31, 2023
    Assignee: SINGAPORE HEALTH SERVICES PTE. LTD.
    Inventor: Salvatore Albani
  • Publication number: 20230326127
    Abstract: Methods and systems for simulating a stent in a coronary artery lumen structure are disclosed. A method of simulating a stent in a coronary artery lumen structure, the method comprises: reconstructing a three-dimensional coronary artery tree from segmented coronary lumen contours; replacing part of the three-dimensional artery tree with a candidate stent structure; and simulating pressure distribution through the coronary artery tree to determine a non-invasive fractional flow reserve through the candidate stent structure.
    Type: Application
    Filed: August 26, 2021
    Publication date: October 12, 2023
    Applicants: Singapore Health Services Pte Ltd, Agency For Science, Technology And Research
    Inventors: Liang ZHONG, Weimin HUANG, Junmei ZHANG, Gaurav CHANDOLA, Soo Teik LIM, Ru San TAN, Swee Yaw TAN
  • Patent number: 11780898
    Abstract: Diagnosis, treatment and prophylaxis of diseases and conditions associated with smooth muscle cell (SMC) dysfunction are provided through the inhibition of IL-11-mediated signalling.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: October 10, 2023
    Assignees: Singapore Health Services PTE LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Sebastian Schaefer, Wei Wen Lim, Benjamin Wei Ming Ng
  • Publication number: 20230285470
    Abstract: The invention relates to a method of generating an induced pluripotent stem cell. The method of the disclosure comprises expressing exogenous nucleic acids encoding the proteins OCT3/4, SOX2, KLF4, LIN28 and L-MYC and the p53-shRNA in a stem cell of the amniotic membrane of the umbilical cord under conditions suitable to reprogram the stem cell, thereby generating the induced pluripotent stem cell. The present invention also refer to an induced pluripotent stem cell population obtainable by the method and an induced pluripotent stem cell population obtained by the method. Further, a pharmaceutical composition comprising the induced pluripotent stem cell of the present invention is concerned. The present invention also relates to a method of differentiating the induced pluripotent stem cell of this invention. In addition, a pharmaceutical composition comprising a differentiated induced pluripotent stem cell obtained by the method is also concerned.
    Type: Application
    Filed: July 15, 2021
    Publication date: September 14, 2023
    Applicants: CELLRESEARCH CORPORATION PTE LTD, SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Chou CHAI, Kah Leong LIM, Toan Thang PHAN
  • Publication number: 20230263780
    Abstract: According to the present disclosure, the use of a nanoliposome in the manufacture of a medicament for the prophylaxis and/or treatment of anterior segment ocular diseases is provided. The nanoliposome comprises a plurality of unsaturated and/or saturated lipids forming at least one lipid bilayer encapsulating a hydrophobic drug comprising tacrolimus, wherein the hydrophobic drug and the plurality of unsaturated and/or saturated lipids have a weight ratio of up to 0.2. The present disclosure also provides for such a nanoliposome and a method of preventing and/or treating anterior segment ocular diseases based on the nanoliposomes.
    Type: Application
    Filed: April 27, 2023
    Publication date: August 24, 2023
    Applicant: Singapore Health Services Pte Ltd
    Inventors: Subramanian VENKATRAMAN, Jayaganesh V. NATARAJAN, Yin Chiang Freddy BOEY, Jodhbir Singh MEHTA, Tina Tzee Ling HOWDEN, Xu Wen NG, Anthony Herr Cheun NG
  • Publication number: 20230212279
    Abstract: Methods of treating and preventing Alport syndrome through inhibiting interleukin 11 (EL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
    Type: Application
    Filed: June 17, 2021
    Publication date: July 6, 2023
    Applicants: Singapore Health Services PTE, LTD., National University of Singapore
    Inventors: Stuart Alexander Cook, Anissa Anindya, Sebastian Schaefer
  • Publication number: 20230213225
    Abstract: An isolation chamber includes a plurality of walls and ceiling defining an internal chamber and a first and second door. The doors seal engagement with the walls. A fan filter unit is arranged to extract air from the internal chamber. The isolation chamber is arranged to couple to a doorway, and the coupling arranged to provide an airtight seal about the doorway.
    Type: Application
    Filed: August 31, 2020
    Publication date: July 6, 2023
    Applicants: THE BIOFACTORY PTE LTD, SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Hairil Rizal ABDULLAH, Mavis TEO, Antonia ZENG, Zihui TAN, Gabriel TAN, Chun Siong LEE, Ron WIGHT, Marcus Hiong Tat TAN
  • Publication number: 20230201776
    Abstract: A graphene oxide-based membrane There is provided a graphene oxide-based membrane comprising a substrate and a plurality of layers of single-layered graphene oxide formed on the substrate, each of the plurality of layers of single-layered graphene oxide is functionalised by at least one diamine functional group, wherein interlayer spacing between two adjacent layers of single-layered graphene oxide is ? 10 Å. The membrane may be comprised in an electrocapacitive unit. There is also provided a method of forming the membrane.
    Type: Application
    Filed: May 14, 2021
    Publication date: June 29, 2023
    Applicants: Singapore University of Technology And Design, Singapore Health Services Pte Ltd.
    Inventors: Hui Ying YANG, Zhi Yi LEONG, Debajyoti Malakar ROY, Sreekanth KODURI
  • Patent number: 11672784
    Abstract: According to the present disclosure, the use of a nanoliposome in the manufacture of a medicament for the prophylaxis and/or treatment of anterior segment ocular diseases is provided. The nanoliposome comprises a plurality of unsaturated and/or saturated lipids forming at least one lipid bilayer encapsulating a hydrophobic drug comprising tacrolimus, wherein the hydrophobic drug and the plurality of unsaturated and/or saturated lipids have a weight ratio of up to 0.2. The present disclosure also provides for such a nanoliposome and a method of preventing and/or treating anterior segment ocular diseases based on the nanoliposomes.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: June 13, 2023
    Assignees: NANYANG TECHNOLOGICAL UNIVERSITY, SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Subramanian Venkatraman, Jayaganesh V. Natarajan, Yin Chiang Freddy Boey, Jodhbir Singh Mehta, Tina Tzee Ling Howden, Xu Wen Ng, Anthony Herr Cheun Ng
  • Patent number: 11655451
    Abstract: The present disclosure relates to methods for culturing human epidermal keratinocytes. When keratinocytes are cultured on plates coated with a laminin containing an alpha-4 chain or an alpha-5 chain, in a xeno-free, chemically defined cell culture medium, they expand efficiently in vitro. Useful cell culture kits for culturing keratinocytes are also described herein, as are methods of using such cells for treatment of burns or chronic wounds.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: May 23, 2023
    Assignees: NATIONAL UNIVERSITY OF SINGAPORE, SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Karl Tryggvason, Monica Suryana Tjin, Alvin Wen Choong Chua
  • Patent number: 11647963
    Abstract: A method of producing an artificial neural network capable of predicting the survivability of a patient, including: storing in an electronic database patient health data comprising a plurality of sets of data, each set having at least one of a first parameter relating to heart rate variability data and a second parameter relating to vital sign data, each set further having a third parameter relating to patient survivability; providing a network of nodes interconnected to form an artificial neural network, the nodes comprising a plurality of artificial neurons, each artificial neuron having at least one input with an associated weight; and training the artificial neural network using the patient health data such that the associated weight of the at least one input of each artificial neuron is adjusted in response to respective first, second and third parameters of different sets of data from the patient health data.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: May 16, 2023
    Assignees: SINGAPORE HEALTH SERVICES PTE LTD., NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Marcus Eng Hock Ong, Zhiping Lin, Wee Ser, Guangbin Huang