Patents Assigned to SINGULAR BIO INC.
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Publication number: 20200325528Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: ApplicationFiled: April 7, 2020Publication date: October 15, 2020Applicant: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Patent number: 10626450Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: GrantFiled: August 11, 2017Date of Patent: April 21, 2020Assignee: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Publication number: 20190284552Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes. The invention also relates to manufacturing and using arrays and analytical approaches based on single molecule detection techniques.Type: ApplicationFiled: May 26, 2017Publication date: September 19, 2019Applicant: Singular Bio, Inc.Inventors: Patrick James Collins, Hywel Bowden Jones
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Publication number: 20190241940Abstract: A method for quantifying labels on a substrate is performed by an electronic device with one or more processors and memory. The method includes obtaining digital data corresponding to a multi-dimensional measurement over the substrate; identifying a first set of sub-portions of the digital data; and, for a respective sub-portion of the first set of sub-portions of the digital data: increasing a quantity of labels, and subtracting a reference signal distribution from the respective sub-portion to obtain subtracted sub-portion data. The method also includes obtaining subtracted digital data. The subtracted digital data includes the subtracted sub-portion data for the respective sub-portion. The method further includes identifying a second set of one or more sub-portions of the subtracted digital data; and, for a respective sub-portion of the second set of one or more sub-portions of the subtracted digital data, increasing a quantity of labels.Type: ApplicationFiled: September 1, 2017Publication date: August 8, 2019Applicant: Singular Bio, Inc.Inventors: Hywel Bowden Jones, Andrea Lynn McEvoy
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Publication number: 20180179586Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: ApplicationFiled: August 11, 2017Publication date: June 28, 2018Applicant: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Publication number: 20180051331Abstract: The invention includes methods for optimally designing probes and analyzing data from sequence-byhybridization and related methods of stretched molecules or other experimental approaches that provide local information. An exemplary method of analyzing a nucleic acid sample may comprise: selecting a group of one or more labeled oligonucleotide probe(s), contacting at least one of the group of the labeled oligonucleotide probe(s) to at least one nucleic acid molecule(s) from the nucleic acid sample, wherein the nucleic acid molecule(s) is stretched, and correlating one or more point(s) of contact to a structural characteristic of the nucleic acid sample. In some embodiments, the nucleic acid molecule(s) is deoxyribonucleic acid (DNA) and/or the method of contacting is hybridization or ligation.Type: ApplicationFiled: April 28, 2017Publication date: February 22, 2018Applicant: Singular Bio, Inc.Inventor: Hywel Bowden Jones
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Publication number: 20180023138Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject. The invention further relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: ApplicationFiled: October 31, 2015Publication date: January 25, 2018Applicant: Singular Bio, Inc.Inventors: Patrick James Collins, Hywel Bowden Jones, Alexandria Hui Wang
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Publication number: 20180023124Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes. The invention also relates to manufacturing and using molecular arrays and analytical approaches based on single molecule detection techniques.Type: ApplicationFiled: February 18, 2016Publication date: January 25, 2018Applicant: Singular Bio, Inc.Inventors: Patrick James Collins, Adrian Nielsen Fehr, Jill Lyndon Herschleb, Hywel Bowden Jones
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Patent number: 9758814Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: GrantFiled: November 23, 2015Date of Patent: September 12, 2017Assignee: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Patent number: 9556429Abstract: Methods are provided for producing a molecular array comprising a plurality of molecules immobilized to a solid substrate at a density which allows individual immobilized molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilization. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.Type: GrantFiled: February 6, 2015Date of Patent: January 31, 2017Assignee: Singular Bio, Inc.Inventor: Kalim Mir
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Patent number: 9481883Abstract: Methods are provided for producing a molecular array comprising a plurality of molecules immoblized to a solid substrate at a density which allows individual immobilized molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilization. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.Type: GrantFiled: July 22, 2015Date of Patent: November 1, 2016Assignee: Singular Bio, Inc.Inventor: Kalim Mir
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Patent number: 9376677Abstract: Methods are provided for producing a molecular array comprising a plurality of molecules immobilized to a solid substrate at a density which allows individual immobilized molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilization. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.Type: GrantFiled: January 14, 2016Date of Patent: June 28, 2016Assignee: Singular Bio, Inc.Inventor: Kalim Mir
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Publication number: 20160160272Abstract: Methods are provided for producing a molecular array comprising a plurality of molecules immobilised to a solid substrate at a density which allows individual immobilised molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilization. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.Type: ApplicationFiled: January 27, 2016Publication date: June 9, 2016Applicant: Singular Bio, Inc.Inventor: Kalim Mir
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Publication number: 20160122754Abstract: Methods are provided for producing a molecular array comprising a plurality of molecules immobilized to a solid substrate at a density which allows individual immobilised molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilization. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.Type: ApplicationFiled: January 14, 2016Publication date: May 5, 2016Applicant: Singular Bio, Inc.Inventor: Kalim Mir
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Publication number: 20160076087Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: ApplicationFiled: November 23, 2015Publication date: March 17, 2016Applicant: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Patent number: 9212394Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: GrantFiled: January 22, 2015Date of Patent: December 15, 2015Assignee: Singular Bio, Inc.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Publication number: 20150337296Abstract: Methods are provided for producing a molecular array comprising a plurality of molecules immoblised to a solid substrate at a density which allows individual immobilised molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilization. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.Type: ApplicationFiled: July 22, 2015Publication date: November 26, 2015Applicant: SINGULAR BIO, INC.Inventor: Kalim Mir
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Publication number: 20150203903Abstract: Methods are provided for producing a molecular array comprising a plurality of molecules immoblised to a solid substrate at a density which allows individual immobilised molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilisation. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.Type: ApplicationFiled: February 6, 2015Publication date: July 23, 2015Applicant: SINGULAR BIO, INC.Inventor: Kalim Mir
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Publication number: 20150167077Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: ApplicationFiled: January 22, 2015Publication date: June 18, 2015Applicant: SINGULAR BIO INC.Inventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Patent number: 9057730Abstract: Methods are provided for producing a molecular array comprising a plurality of molecules immoblised to a solid substrate at a density which allows individual immobilised molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilisation. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.Type: GrantFiled: April 25, 2012Date of Patent: June 16, 2015Assignee: Singular Bio, Inc.Inventor: Kalim Mir