Patents Assigned to Singulex, Inc.
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Patent number: 10288623Abstract: Disclosed are methods for diagnosing, staging, and predicting risk for developing rheumatoid arthritis and other inflammatory diseases, and methods for identifying treatment responders and non-responders.Type: GrantFiled: September 4, 2014Date of Patent: May 14, 2019Assignee: SINGULEX, INC.Inventors: John Allan Todd, Quynh Anh Thuc Lu, Sara Jane Le
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Patent number: 10107752Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.Type: GrantFiled: November 2, 2015Date of Patent: October 23, 2018Assignee: Singulex, Inc.Inventor: Richard Livingston
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Patent number: 9977031Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.Type: GrantFiled: November 10, 2016Date of Patent: May 22, 2018Assignees: Singulex, Inc., The Regents of the University of CaliforniaInventors: Philippe Goix, Robert Puskas, John Todd, Richard Livingston, Douglas Held, Allan H. B. Wu
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Patent number: 9823194Abstract: Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.Type: GrantFiled: June 18, 2015Date of Patent: November 21, 2017Assignee: Singulex, Inc.Inventors: Philippe J. Goix, Robert Puskas, John Todd, Richard A. Livingston, Douglas Held
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Patent number: 9719999Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.Type: GrantFiled: October 23, 2015Date of Patent: August 1, 2017Assignees: Singulex, Inc., The Regents of the University of CaliforniaInventors: Philippe J. Goix, Robert Puskas, John Todd, Richard Livingston, Douglas Held, Allan H. B. Wu
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Patent number: 9494598Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.Type: GrantFiled: March 12, 2013Date of Patent: November 15, 2016Assignees: Singulex, Inc., The Regents of the University of CaliforniaInventors: Philippe Goix, Robert Puskas, John Todd, Richard Livingston, Douglas Held, Allan H. B. Wu
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Patent number: 9239284Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.Type: GrantFiled: December 22, 2014Date of Patent: January 19, 2016Assignee: Singulex, Inc.Inventor: Richard Livingston
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Patent number: 9182405Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.Type: GrantFiled: March 13, 2013Date of Patent: November 10, 2015Assignees: Singulex, Inc., The Regents of the University of CaliforniaInventors: Philippe Goix, Robert Puskas, John Todd, Richard Livingston, Douglas Held, Allan H. B. Wu
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Patent number: 9068991Abstract: Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnI, BNP) and vascular inflammation (IL-6, TNF?, IL-17a) biomarkers provided a sensitivity of 94% for association with CHF.Type: GrantFiled: March 9, 2013Date of Patent: June 30, 2015Assignee: Singulex, Inc.Inventors: Philippe J. Goix, Robert Puskas, John Todd, Richard Livingston, Douglas Held, Sara Le
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Patent number: 9063131Abstract: Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.Type: GrantFiled: March 14, 2013Date of Patent: June 23, 2015Assignee: Singulex, Inc.Inventors: Philippe J. Goix, Robert Puskas, John Todd, Richard A. Livingston, Douglas Held
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Patent number: 9040305Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles, e.g., protein molecules, or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.Type: GrantFiled: June 22, 2007Date of Patent: May 26, 2015Assignee: Singulex, Inc.Inventors: Philippe J. Goix, Robert Puskas, John Todd, Richard A. Livingston, Douglas Held
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Patent number: 8917392Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.Type: GrantFiled: March 9, 2013Date of Patent: December 23, 2014Assignee: Singulex, Inc.Inventor: Richard Livingston
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Publication number: 20140342468Abstract: The present invention provides single molecule analyses of species of use in analytical, diagnostic or prognostic assays. In exemplary embodiments, the assays utilize samples prepared by novel methods, affording assays of unexpected sensitivity and robustness. The method is described in a non-limiting manner by reference to cytokine assays.Type: ApplicationFiled: March 4, 2014Publication date: November 20, 2014Applicant: Singulex, Inc.Inventors: John Todd, Quynhanh Lu, Robert Freese
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Publication number: 20140227715Abstract: Methods, kits, and systems for determining vulnerable plaque burden in a subject. The methods involve measuring an amount of at least one biomarker in a blood sample from the subject, wherein the at least one biomarker is selected from the group consisting of vascular endothelial growth factor-A (VEGF), cardiac troponin I (cTnI), and matrix metalloproteinase-9 (MMP-9). The concentration of these biomarkers in a sample from the subject are used to determine vulnerable plaque burden in the subject.Type: ApplicationFiled: February 14, 2014Publication date: August 14, 2014Applicant: Singulex, Inc.Inventors: John Allan Todd, Quynh Anh Thuc Lu, Jeffrey David Greenberg
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Publication number: 20140206632Abstract: A method for determining the risk, severity or progression of cardiovascular disease, such as cardiac heart failure. A method for determining the likelihood of admission to the hospital for cardiac heart failure. The methods include determining the concentration of ET-1 and the concentration of one or more of biomarkers selected from the group consisting of cardiac troponin (e.g., cTnI, cTnT), VEGF, BNP, NT-proBNP, and IL-6 in a blood, serum or plasma sample from the patient.Type: ApplicationFiled: January 22, 2014Publication date: July 24, 2014Applicant: Singulex, Inc.Inventors: John Todd, Joel Estis, Victoria Torres
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Patent number: 8685711Abstract: Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.Type: GrantFiled: March 25, 2010Date of Patent: April 1, 2014Assignee: Singulex, Inc.Inventors: Philippe J. Goix, Robert Puskas, John Todd, Richard A. Livingston, Douglas Held
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Patent number: 8634075Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.Type: GrantFiled: March 9, 2013Date of Patent: January 21, 2014Assignee: Singulex, Inc.Inventor: Richard Livingston
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Publication number: 20130288383Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.Type: ApplicationFiled: March 13, 2013Publication date: October 31, 2013Applicant: Singulex, Inc.Inventor: Singulex, Inc.
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Publication number: 20130267039Abstract: The present invention provides single molecule analyses of species of use in analytical, diagnostic or prognostic assays. In exemplary embodiments, the assays utilize samples prepared by novel methods, affording assays of unexpected sensitivity and robustness. The method is described in a non-limiting manner by reference to cytokine assays.Type: ApplicationFiled: March 9, 2013Publication date: October 10, 2013Applicant: SINGULEX, INC.Inventors: John Todd, Quynhanh Lu, Robert Freese
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Publication number: 20130261009Abstract: Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnI, BNP) and vascular inflammation (IL-6, TNF?, IL-17a) biomarkers provided a sensitivity of 94% for association with CHF.Type: ApplicationFiled: March 9, 2013Publication date: October 3, 2013Applicant: SINGULEX, INC.Inventors: Philippe J. Goix, Robert Puskas, John Todd, Richard Livingston, Douglas Held, Sara Le
