Abstract: Several methods for the preparation of an amorphous powder comprising a 1:1 stoichiometric mixture of the trisodium salts of Valsartan and Sacubitril are described, as well as the resulting amorphous powder, pharmaceutical compositions containing it, and their use in the treatment of essential hypertension and/or cardiac failure.
Type:
Application
Filed:
July 12, 2016
Publication date:
December 13, 2018
Applicant:
Quimica Sintetica, S.A.
Inventors:
Giuseppe Barreca, Giampiero Ventimiglia, Sonja Bellomi
Abstract: The invention relates to a process for the preparation of Levomilnacipran or salts thereof, compounds useful in the treatment of depression, with high yield.
Abstract: This invention relates to an ampoule opening device (1) for the opening of glass ampoules (100) of the type used in particular in the pharmaceutical field for injection substances. The device according to this invention allows opening, by rupture of the neck of the ampoule, glass ampoules of different capacities (and therefore of sizes), by generating a non irregular rupture edge and therefore minimizing the creation of glass fragments that may fall into the substance contained within the ampoule. Moreover, the device object of this invention allows avoiding contact of the user's fingers with the neck and the cap of the ampoule, thereby preventing any risk of accidental injuries. The device object of this invention allows obtaining excellent results in terms of quality of the rupture edge of the ampoule neck and of repeating the result obtained thanks to the fact that the device allows to apply to the ampoule a constant rupture bending moment for ampoules of the same type.
Abstract: This invention relates to an injectable pharmaceutical composition based on chloroprocaine or salts and/or derivatives thereof for use in central loco-regional anesthesia by intrathecal administration in repeated doses. Unexpectedly, the intrathecal administration in repeated doses of chloroprocaine does not increase the neurotoxicity of this drug in statistically significant manner.
Type:
Grant
Filed:
December 11, 2013
Date of Patent:
November 29, 2016
Assignee:
SINTETICA S.A.
Inventors:
Augusto Mitidieri, Elisabetta Donati, Nicola Caronzolo
Abstract: The present invention concerns a new use for a composition containing chloroprocaine HCl, and in particular its use for the manufacture of a drug for intrathecal narcosis. The present invention also concerns a new composition containing chloroprocaine HCl, being particularly suited to this new use, as well as a new method for manufacturing the composition.
Abstract: The present invention concerns new preservative-free hyperbaric compositions of prilocaine HCI intended for use in intrathecal narcosis, characterized by high stability at ambient temperature (15° C. -27° C.). The present invention also concerns a method for manufacturing said compositions.
Abstract: This invention relates to a process for obtaining levofloxacin free from salts. In this process the starting product used is the compound (V), alkaline hydrolysis of which within a water-(C1-C4)alcohol mixture, and subsequent neutralisation and separation of the salts, leads to levofloxacin free from salts, without need to carry out any final step of extraction and without using halogenated solvents. One characteristic of the process described is that no extractions are necessary in the final step of the process.
Type:
Application
Filed:
December 15, 2005
Publication date:
March 12, 2009
Applicant:
Quimica Sintetica, S.A.
Inventors:
Francisco Palomo Nicolau, Antonio Cosme Gomez, Rafael Martin Sanchez
Abstract: The present invention concerns new preservative-free hyperbaric compositions of prilocaine HCI intended for use in intrathecal narcosis, characterized by high stability at ambient temperature (15° C.-27° C.). The present invention also concerns a method for manufacturing said compositions.
Abstract: The present invention relates to a composition, particularly useful in paint. This composition is defined in that it contains, for successive or simultaneous addition:
an isocyanate which is at least partially masked, having a glass transition temperature (sometimes denoted by the abbreviation Tg) of at least 20° C., advantageously of at least 40° C., and a degree of liberation at 120° C. of not more than 5%;
a polyol having the following characteristics:
a glass transition temperature (sometimes denoted by the abbreviation Tg) which is at least equal to about 40° C., advantageously at least equal to about 50° C.;
a hydroxyl number at least equal to about 10 mg/g, advantageously at least equal to about 15 mg/g;
an average molecular mass Mn at least equal to about 1000 g/mol and advantageously to 2000 g/mol.
Type:
Grant
Filed:
July 31, 2001
Date of Patent:
September 30, 2003
Assignees:
Rhodia Chimie, Resinas Sinteticas S. A.
Inventors:
Pierre Ardaud, Francis John Williams, Jean-Marie Bernard, Bernard Vogin
Abstract: It comprises reducing the hydroxy ester of formula (X) by reacting it in DMF and then with an iminium salt of formula (XIII) formed in situ with thionyl chloride and dimethylformamide, and subsequent reduction with an appropriate reducing agent to form the ester of formula (XII), which is then reacted with dimethylamine in a polyhydroxylated solvent medium at an appropriate
Abstract: The present invention relates to a composition, particularly useful in paint. This composition is defined in that it contains, for successive or simultaneous addition:
an isocyanate which is at least partially masked, having a glass transition temperature (sometimes denoted by the abbreviation Tg) of at least 20° C., advantageously of at least 40° C., and a degree of liberation at 120° C. of not more than 5%;
a polyol having the following characteristics:
a glass transition temperature (sometimes denoted by the abbreviation Tg) which is at least equal to about 40° C., advantageously at least equal to about 50° C.;
a hydroxyl number at least equal to about 10 mg/g, advantageously at least equal to about 15 mg/g;
an average molecular mass Mn at least equal to about 1000 g/mol and advantageously to 2000 g/mol.
Type:
Grant
Filed:
February 1, 1999
Date of Patent:
September 18, 2001
Assignees:
Rhodia Chimie, Resinas Sinteticas S.A.
Inventors:
Pierre Ardaud, Francis John Williams, Jean-Marie Bernard, Bernard Vogin
Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
Type:
Grant
Filed:
November 20, 1991
Date of Patent:
December 21, 1993
Assignee:
Sintetica S.A.
Inventors:
Michel Schneider, Daniel Bichon, Philippe Bussat, Jerome Puginier, Eva Hybl-Sutherland
Abstract: A process for producing 1-4 butanediol comprising reacting 1-4 butynediol with hydrogen in the presence of a catalyst comprising ruthenium and palladium in a weight ratio of about 4:1, at a temperature of from 60.degree. to 180.degree. C. and at a pressure of between 1 to 50 bars.
Type:
Grant
Filed:
November 12, 1981
Date of Patent:
March 20, 1984
Assignee:
S.I.S.A.S. Societa Italina Serie Acetica Sintetica S.p.A.
Abstract: The process for the preparation of 1,4-butynediol through the reaction of acetylene with formaldehyde in the presence of a catalytic metal, preferably copper, is improved by using, as the support of the catalytic metal, a molecular sieve or synthetic zeolite to which the catalytic metal is chemically bonded through an ion exchange reaction.There are obtained increased production rates and selectivity and the polymer of acetylene, namely cuprene, is essentially prevented from being formed.
Type:
Grant
Filed:
October 17, 1979
Date of Patent:
September 8, 1981
Assignee:
Societa Italiana Serie Acetica Sintetica S.p.A.
Inventors:
Franco Codignola, Giorgio Vergini, Paolo Gronchi, Paolo Centola