Patents Assigned to SiPhox, Inc.
  • Publication number: 20240094204
    Abstract: An apparatus for photonic biosensors for multiplexed diagnostics and a method of use are disclosed. The apparatus includes a portable device configured for point-of-care diagnostics. The portable device includes a photonic sensor chip that includes one or more resonators that is substantially in contact with at least a fluid that includes one or more analytes and the reader device communicatively connected to the photonic sensor chip that includes at least a light source and the reader device is configured to provide an input optical signal using the at least a light source, receive the one or more sensor signals from the photonic sensor chip and determine one or more characteristics of the one or more analytes as a function of the one or more sensor signals and a connecting system, wherein the connecting system is configured to connect the photonic sensor chip and the reader device.
    Type: Application
    Filed: March 24, 2023
    Publication date: March 21, 2024
    Applicant: SiPhox, Inc.
    Inventors: Sarat Gundavarapu, Ebrahim Al Johani, Diedrik Rene Vermeulen
  • Publication number: 20240058814
    Abstract: An apparatus for performing analyte detection, wherein the apparatus comprises an optoelectronic reader device, the optoelectronic reader device comprising a microfluidic subassembly comprising a microfluidic pump, the microfluidic pump configured to route the flow of at least a fluid, wherein the at least a fluid contains an analyte, and at least a reservoir configured to contain the at least a fluid, an optics subassembly, the optics subassembly comprising an optical device having at least one light source directed at the at least a fluid, and a sensor device configured to sense the at least a fluid and detect at least an optical property of the analyte, and a portable device, wherein the portable device is configured for point of care diagnostics.
    Type: Application
    Filed: March 21, 2023
    Publication date: February 22, 2024
    Applicant: SiPhox, Inc.
    Inventors: Sarat Gundavarapu, Diedrik Rene Vermeulen
  • Publication number: 20230393143
    Abstract: Disclosed herein are methods of allergen testing and IgG depletion. In some embodiments, testing for IgE antibodies specific for an allergen may be improved by first depleting IgG in a sample. In some embodiments, IgG may be depleted using Biotinylated Protein G (bPG) and streptavidin (SA).
    Type: Application
    Filed: May 18, 2023
    Publication date: December 7, 2023
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Eric Hsu, Elaine Taine, Xabier Arias, Yulia Rybakova
  • Publication number: 20230384319
    Abstract: An apparatus for detecting an analyte, the apparatus includes a biosensor having at least a sensor surface functionalized with a binding ligand, wherein the at least a sensor surface is configured to selectively bind to an analyte, a microfluidic device configured to receive a sample fluid containing the analyte, incubate the biosensor with the sample fluid, and conjugate an anti-analyte molecule with a nanoparticle, wherein the nanoparticle is configured to provide a binding signal to the biosensor when the nanoparticle binds to the analyte bound to the binding ligand on the at least a sensor surface, and incubate the biosensor with the analyte bound to the binding ligand on the at least a sensor surface with the anti-analyte molecule conjugated with the nanoparticle, and a sensor circuit communicatively connected to the biosensor, wherein the sensor circuit is configured to detect at least an analyte characteristic of the analyte.
    Type: Application
    Filed: May 18, 2023
    Publication date: November 30, 2023
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Eric Hsu, Elaine Taine, Xabier Arias, Yulia Rybakova
  • Publication number: 20230371869
    Abstract: Apparatus of a multipurpose fluid extraction device for diagnostics and method of use are disclosed. The apparatus includes a fluid extraction system, wherein the fluid extraction system is configured to extract a fluid from a user, a microfluidic assembly, wherein the microfluidic assembly is configured to provide a flow of extracted fluid, where the microfluidic assembly includes a microfluidic channel, a photonic sensor, wherein the photonic sensor is configured to output a sensor signal to a reader device that is configured to detect one or more characteristics of the extracted fluid as a function of the sensor signal, an assay component fluidically connected to the microfluidic assembly, wherein the assay component is configured for testing the extracted fluid and a fluid collecting reservoir fluidically connected to the microfluidic assembly, wherein the fluid collecting reservoir is configured to collect the extracted fluid from the microfluidic assembly.
    Type: Application
    Filed: May 18, 2023
    Publication date: November 23, 2023
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Diedrik Rene Vermeulen
  • Publication number: 20230372934
    Abstract: An apparatus for controlling assay steps using active flow components, the apparatus includes a microfluidic device containing a reservoir configured to contain a fluid and microfluidic channels connected to the reservoir, wherein the microfluidic channels are configured to create a microfluidic environment for an assay, active flow components, a sensor device configured to detect a sensed property of the fluid, and an external device connected to the microfluidic device including actuators, wherein the actuators are configured to connect the active flow components using a mechanical interface and initiate active flow processes corresponds to assay steps of the assay based on the active flow components, and a reading device configured to read the sensed property of the fluid from the sensor device, wherein the active flow components are configured to flow the fluid bi-directionally through the sensor device within the microfluidic environment based on active flow processes.
    Type: Application
    Filed: May 18, 2023
    Publication date: November 23, 2023
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Armando Paredes, Diedrik Rene Vermeulen
  • Publication number: 20230264195
    Abstract: An apparatus for performing microfluidic-based biochemical assays, the apparatus includes a microfluidic device, wherein the microfluidic device comprises at least a microfluidic feature comprising at least a reservoir configured to contain at least a fluid, and at least an alignment feature for positioning and attaching a sensor device, wherein the at least an alignment feature is not contacting the at least a microfluidic feature, at least a sensor device configured to be in sensed communication with the at least a fluid and detect at least a sensed property, and at least a flow component fluidically connected to the at least a microfluidic feature configured to flow the at least a fluid through the at least a sensor device.
    Type: Application
    Filed: March 15, 2023
    Publication date: August 24, 2023
    Applicant: SiPhox, Inc.
    Inventor: Armando Paredes
  • Publication number: 20230012903
    Abstract: Aspects relate to devices, systems, and methods for non-invasive testing. The device may include a cartridge that analyzes a nasopharyngeal swabbing sample. The device may also include first and second waveguides, where each waveguide is configured to propagate an electromagnetic (EM) wave.
    Type: Application
    Filed: July 7, 2022
    Publication date: January 19, 2023
    Applicant: SiPhox, Inc.
    Inventors: Yulia Rybakova, Cole Chapman, Gordon Siek, Jordan Cobb, Ebrahim Aljohani
  • Publication number: 20230012094
    Abstract: Aspects relate to systems and methods for fluid sensing using passive flow. An exemplary system includes a microfluidic device, the microfluidic device including at least a reservoir configured to contain at least a fluid and at least a passive flow component in fluidic communication with the at least a reservoir and configured to flow the at least a fluid with predetermined flow properties, at least an sensor device configured to be in sensed communication with the at least a fluid and detect at least a sensed property; and at least an sensor interface configured to wet at least a surface of the at least a sensor device with the at least a fluid.
    Type: Application
    Filed: July 7, 2022
    Publication date: January 12, 2023
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Pengguan Yu, Diedrik Rene Vermeulen
  • Publication number: 20220049298
    Abstract: A method of tagged-base DNA sequencing readout on waveguide surfaces includes immobilizing, a surface of a waveguide, a nucleotide fragment, exposing the nucleotide fragment to a first plurality of capped nucleotides, wherein the first plurality of capped nucleotides include a first plurality of nucleotide types, each distinct nucleotide type has a distinct capping agent, and each distinct capping agent has a distinct optical signature, severing base pair connections between the at least a nucleotide fragment and the first plurality of capped nucleotides, wherein the nucleotide fragment remains attached and a first single nucleotide, of the first plurality of capped nucleotides, remains immobilized on a nucleotide binding locus adjacent to the first nucleotide sequence, and detecting a first distinct optical signature of a first distinct capping agent of the first single nucleotide using the waveguide.
    Type: Application
    Filed: August 16, 2021
    Publication date: February 17, 2022
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Diedrik Rene Vermeulen
  • Publication number: 20210382515
    Abstract: Aspects relate to methods and systems for optical matrix calculation. An exemplary system includes at least a first light source configured to output at least a first optical output having a first wavelength, at least a second light source configured to output at least a second optical output having a second wavelength substantially different from the first wavelength, at least an optical modulator configured to modulate the at least a first optical output, at least an optical matrix multiplier configured to perform at least two matrix multiplications, a first matrix multiplication as a function of the first optical output and a second matrix multiplication as a function of the second optical output, and at least a photodetector configured to measure the at least a first optical output and the at least a second optical output.
    Type: Application
    Filed: June 3, 2021
    Publication date: December 9, 2021
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Diedrik Rene Vermeulen
  • Publication number: 20210381018
    Abstract: Aspects relate to systems and methods for high-contrast cleavage detection. An exemplary method includes a plurality of probes, wherein at least a probe of the plurality of probes comprises a high-contrast agent, a waveguide configured to propagate an electromagnetic (EM) wave, wherein the waveguide includes a surface upon which the plurality of probes are immobilized, wherein the surface is configured to provide communication between the EM wave and the high-contrast agent, a primary cleaving agent proximal the plurality of probes, wherein the primary cleaving agent and the plurality of probes are configured to selectively cleave the at least a probe as a result of the primary cleaving agent being in presence of an analyte, and a sensor in communication with the waveguide and configured to detect cleaving of the at least a probe by way of the EM wave.
    Type: Application
    Filed: June 3, 2021
    Publication date: December 9, 2021
    Applicant: SiPhox, Inc.
    Inventor: Michael Dubrovsky