Abstract: The present disclosure discusses a novel cup designed with an integrated lateral flow assay (LFA) to detect the presence of caffeine in coffee. The LFA is housed in a specialized chamber in a selected position or at the bottom of the cup. This chamber is designed with an opening only at the bottom, which traps air when the cup is filled with liquid, ensuring that only the bottom part of the LFA is wetted by the beverage. This design allows the LFA to function effectively, provided the coffee does not contain milk or other additives that could interfere with the test. The invention includes a transparent window on the cup to allow the user to observe the LFA and determine the caffeine content visually. Additionally, the cup can be modified or retrofitted with LFA chambers that can be attached to existing cups or stand inside them like a straw.

Abstract: Disclosed herein are integrated photonics assemblies, circuits, systems and methods therefor. The systems can include a first integrated photonics assembly having a first functionality, in which the first assembly includes a plurality of modular photonic integrated subcircuits. Each subcircuit can be pre-fabricated and can be configured to transfer light to and receive light from another subcircuit based on the first functionality. An output port of a first subset of the subcircuits can be configured to be aligned with an input port of a second subset of the subcircuits. At least one subcircuit can be configured to be removed from the first integrated photonics assembly and connected to a second integrated photonics assembly having a second functionality. The first integrated photonics assembly can be different from the second integrated photonics assembly and the first functionality can be different from the second functionality.

Abstract: Disclosed herein are biosensors for biosensing including a sensor photonic integrated circuit (PIC) configured to be positioned inside a human body. The sensor PIC includes one or more optical analyte sensors each functionalized by a respective layer of binding ligands. The biosensors further include a reader system optically coupled to the sensor PIC. The reader system is configured to provide optical signals to the one or more optical analyte sensors and receive signals provided by the one or more optical analyte sensors. The reader system is further configured to determine one or more characteristics of one or more analytes sensed by the one or more optical analyte sensors based on the signals provided by the one or more optical analyte sensors.

Abstract: A device for optical biosensing using magnetic particles includes an optical waveguide at least a light source at the input of the optical waveguide, an evanescent field generated at the exterior surface with an effective range, a plurality of magnetic particles tethered to the exterior surface, a magnetic field generator, the magnetic field generator configured to alternate between a first state in which the plurality of magnetic particles extend outside of the effective range and a second state in which the plurality of magnetic particles do not extend outside of the effective range, a capture reagent disposed on the exterior surface that holds a first quantity of magnetic particles within the effective range when the magnetic field generator is in the second state and an analyte of interest is present, and a second quantity when not, producing a first output signal and a second output signal respectively.

Abstract: Aspects relate to methods and systems for optical matrix calculation. An exemplary system includes at least a first light source configured to output at least a first optical output having a first wavelength, at least a second light source configured to output at least a second optical output having a second wavelength substantially different from the first wavelength, at least an optical modulator configured to modulate the at least a first optical output, at least an optical matrix multiplier configured to perform at least two matrix multiplications, a first matrix multiplication as a function of the first optical output and a second matrix multiplication as a function of the second optical output, and at least a photodetector configured to measure the at least a first optical output and the at least a second optical output.

Abstract: An apparatus for pluggable inter-chip optical connector may include a first sub-assembly, including at least a first photonic chip, a first high tolerance grating coupler element configured to interface with at least a second photonic chip, and a first set of one or more alignment features, and a second sub-assembly including the at least a second photonic chip, wherein the at least a second photonic chip includes a sensing region, and a second set of one or more alignment features, wherein the second set of one or more alignment features are configured to plug into the first sub-assembly at the first set of one or more alignment features, wherein attaching the first sub-assembly to the second sub-assembly using the first set of alignment features and the second set of alignment features places the first high tolerance grating coupler in optical communication with the second high tolerance grating coupler.

Abstract: An apparatus for performing analyte detection, wherein the apparatus comprises an optoelectronic reader device, the optoelectronic reader device comprising a microfluidic subassembly comprising a microfluidic pump, the microfluidic pump configured to route the flow of at least a fluid, wherein the at least a fluid contains an analyte, and at least a reservoir configured to contain the at least a fluid, an optics subassembly, the optics subassembly comprising an optical device having at least one light source directed at the at least a fluid, and a sensor device configured to sense the at least a fluid and detect at least an optical property of the analyte, and a portable device, wherein the portable device is configured for point of care diagnostics.

Abstract: An apparatus for the extraction and collection of bodily fluids is disclosed. The apparatus includes a housing configured to receive a body part, wherein the housing comprises an upper portion and a lower portion. The housing includes an end cap removably attached to the upper portion of the housing, wherein the end cap comprises a ribbed connector. The housing additionally includes a first aperture located on the lower portion of the housing. The apparatus includes a gasket mechanically attached to the lower portion of the housing. The apparatus includes a suction device fluidically connected to the ribbed connector of the end cap using a hose. The apparatus includes a fluid collection device configured to extract bodily fluids from the body part as a function of the negative pressure environment, wherein the fluid collection device is removably attached to the end cap.

Abstract: An apparatus for performing microfluidic-based biochemical assays, the apparatus includes a microfluidic device, wherein the microfluidic device comprises at least a microfluidic feature comprising at least a reservoir configured to contain at least a fluid, and at least an alignment feature for positioning and attaching a sensor device, wherein the at least an alignment feature is not contacting the at least a microfluidic feature, at least a sensor device configured to be in sensed communication with the at least a fluid and detect at least a sensed property, and at least a flow component fluidically connected to the at least a microfluidic feature configured to flow the at least a fluid through the at least a sensor device.

Abstract: An apparatus for actuating of fluids in a biosensor cartridge, the apparatus includes a microfluidic device, the microfluidic device includes a microfluidic circuit comprising at least a reservoir configured to contain at least a fluid and an active flow component in fluidic communication with the at least a reservoir, wherein the active flow component comprises a barrel and a plunger at a first position within the barrel, and an actuator configured to initiate an active flow process, wherein initiating the active flow process comprises accepting the plunger using a mechanical interface mechanically communicated to the actuator and moving the plunger within the barrel from the first position to a second position based on predetermined flow properties, and flow the at least a fluid unidirectionally as a function of the active flow process.

Abstract: A bodily fluid collection assembly, the assembly includes a collection device including a tube including a chemical lining, a cap, and a fastener wherein the collection device is attached to a multipurpose fluid extraction device including a fluid extraction system, a microfluidic assembly, wherein the microfluidic assembly is configured to provide a flow of the extracted fluid, wherein the microfluidic assembly includes a microfluidic channel, an assay component fluidically connected to the microfluidic assembly, wherein the assay component is configured to test the extracted fluid, and a fluid collecting reservoir fluidically connected to the microfluidic assembly, wherein the fluid collecting reservoir is configured to collect the extracted fluid from the microfluidic assembly.

Abstract: Disclosed herein are automated biosensing devices for biosensing including a set of sensor units organized in an array. Each of the sensor units includes an optical reader optically coupled to a corresponding sensor photonic integrated circuit (PIC). Each sensor PIC includes one or more optical analyte sensors each functionalized by a respective layer of binding ligands. Each optical reader is configured to provide optical signals to the one or more optical analyte sensors of the corresponding sensor PIC. An automated biosensing device can further include a robotic dipping head configured to dip each of the sensor PICs into a respective test sample.

Abstract: Disclosed herein are biosensors for biosensing including a sensor photonic integrated circuit (PIC) configured to be positioned inside a human body. The sensor PIC includes one or more optical analyte sensors each functionalized by a respective layer of binding ligands. The biosensors further include a reader system optically coupled to the sensor PIC. The reader system is configured to provide optical signals to the one or more optical analyte sensors and receive signals provided by the one or more optical analyte sensors. The reader system is further configured to determine one or more characteristics of one or more analytes sensed by the one or more optical analyte sensors based on the signals provided by the one or more optical analyte sensors.

Abstract: An apparatus for photonic biosensors for multiplexed diagnostics and a method of use are disclosed. The apparatus includes a portable device configured for point-of-care diagnostics. The portable device includes a photonic sensor chip that includes one or more resonators that is substantially in contact with at least a fluid that includes one or more analytes and the reader device communicatively connected to the photonic sensor chip that includes at least a light source and the reader device is configured to provide an input optical signal using the at least a light source, receive the one or more sensor signals from the photonic sensor chip and determine one or more characteristics of the one or more analytes as a function of the one or more sensor signals and a connecting system, wherein the connecting system is configured to connect the photonic sensor chip and the reader device.

Abstract: An apparatus for performing analyte detection, wherein the apparatus comprises an optoelectronic reader device, the optoelectronic reader device comprising a microfluidic subassembly comprising a microfluidic pump, the microfluidic pump configured to route the flow of at least a fluid, wherein the at least a fluid contains an analyte, and at least a reservoir configured to contain the at least a fluid, an optics subassembly, the optics subassembly comprising an optical device having at least one light source directed at the at least a fluid, and a sensor device configured to sense the at least a fluid and detect at least an optical property of the analyte, and a portable device, wherein the portable device is configured for point of care diagnostics.

Abstract: Disclosed herein are methods of allergen testing and IgG depletion. In some embodiments, testing for IgE antibodies specific for an allergen may be improved by first depleting IgG in a sample. In some embodiments, IgG may be depleted using Biotinylated Protein G (bPG) and streptavidin (SA).

Abstract: An apparatus for detecting an analyte, the apparatus includes a biosensor having at least a sensor surface functionalized with a binding ligand, wherein the at least a sensor surface is configured to selectively bind to an analyte, a microfluidic device configured to receive a sample fluid containing the analyte, incubate the biosensor with the sample fluid, and conjugate an anti-analyte molecule with a nanoparticle, wherein the nanoparticle is configured to provide a binding signal to the biosensor when the nanoparticle binds to the analyte bound to the binding ligand on the at least a sensor surface, and incubate the biosensor with the analyte bound to the binding ligand on the at least a sensor surface with the anti-analyte molecule conjugated with the nanoparticle, and a sensor circuit communicatively connected to the biosensor, wherein the sensor circuit is configured to detect at least an analyte characteristic of the analyte.

Abstract: An apparatus for controlling assay steps using active flow components, the apparatus includes a microfluidic device containing a reservoir configured to contain a fluid and microfluidic channels connected to the reservoir, wherein the microfluidic channels are configured to create a microfluidic environment for an assay, active flow components, a sensor device configured to detect a sensed property of the fluid, and an external device connected to the microfluidic device including actuators, wherein the actuators are configured to connect the active flow components using a mechanical interface and initiate active flow processes corresponds to assay steps of the assay based on the active flow components, and a reading device configured to read the sensed property of the fluid from the sensor device, wherein the active flow components are configured to flow the fluid bi-directionally through the sensor device within the microfluidic environment based on active flow processes.

Abstract: Apparatus of a multipurpose fluid extraction device for diagnostics and method of use are disclosed. The apparatus includes a fluid extraction system, wherein the fluid extraction system is configured to extract a fluid from a user, a microfluidic assembly, wherein the microfluidic assembly is configured to provide a flow of extracted fluid, where the microfluidic assembly includes a microfluidic channel, a photonic sensor, wherein the photonic sensor is configured to output a sensor signal to a reader device that is configured to detect one or more characteristics of the extracted fluid as a function of the sensor signal, an assay component fluidically connected to the microfluidic assembly, wherein the assay component is configured for testing the extracted fluid and a fluid collecting reservoir fluidically connected to the microfluidic assembly, wherein the fluid collecting reservoir is configured to collect the extracted fluid from the microfluidic assembly.

Abstract: An apparatus for performing microfluidic-based biochemical assays, the apparatus includes a microfluidic device, wherein the microfluidic device comprises at least a microfluidic feature comprising at least a reservoir configured to contain at least a fluid, and at least an alignment feature for positioning and attaching a sensor device, wherein the at least an alignment feature is not contacting the at least a microfluidic feature, at least a sensor device configured to be in sensed communication with the at least a fluid and detect at least a sensed property, and at least a flow component fluidically connected to the at least a microfluidic feature configured to flow the at least a fluid through the at least a sensor device.