Abstract: A device is provided for delivering a predetermined volume of at least one substance within a body cavity of a subject. The device contains a) a capsule for containing the predetermined volume of substances; b) a delivery end, having at least one orifice of diameter D, for placement in proximity to the body cavity; c) a valve mechanically connectable to the capsule, having at least two configurations: (i) an active configuration in which the valve enables delivery of the substances; and (ii) an inactive configuration, in which the valve prevents delivery of the substances from the capsule to the body cavity; and d) a fluid tight chamber configured to contain predetermined volume Vgas of pressurized gas at a predetermined pressure, Pgas. The capsule further contains at least one mixing mechanism that mixes the substances and the pressurized gas after the valve is reconfigured to the active configuration.

Abstract: The present invention provides a device for delivering a predetermined amount of at least one substance to a body orifice of a subject; comprising: a. a container for containing said at least one substance; b. a delivery end for placement in proximity to said orifice, said delivery end being in fluid communication with said container; c. a valve mechanically connectable to said container, characterized by at least two configurations: (i) an ACTIVE CONFIGURATION in which said valve enables delivery of predetermined amount of said substance from said container to said body orifice via said delivery end; and, (ii) an INACTIVE CONFIGURATION, in which said valve prevents delivery of said predetermined amount of said substance from said container to said body orifice; d. a trigger mechanism adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION, and vice versa; e. a fluid tight chamber.

Abstract: A device for delivering a predetermined amount of a substance within at least one body cavity of a subject, where the predetermined amount is at an effective amount for treatment of obesity or binge eating disorder. The device includes (a) A volume to contain the predetermined amount of the substance. (b) A delivery end placeable in proximity to the body cavity. The delivery end is in fluid communication with the volume and comprises at least one orifice. (c) A valve mechanically connected to the volume, with at least two configurations: (i) an active configuration configured to deliver the predetermined amount of the substance; and, (ii) an inactive configuration, in which the valve prevents delivery of the predetermined amount of the substance. (d) A fluid tight chamber configured to contain a predetermined volume of pressurized gas at a predetermined pressure.

Abstract: A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.

Abstract: A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.

Abstract: A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.

Abstract: The present invention provides a two-step mechanism for delivering a flowable substance to the nasal passages, comprising: a. a nosepiece adapted to be in fluid connection with said nasal passages; b. at least one air-tight enclosure, comprising predetermined amount of compressed gas in the same; said compressed gas is pressurized to predetermined amount of pressure; c. a charging mechanism, fluidly connected with said air-tight enclosure, characterized by at least two configurations: a retracted position and an extended position; where, when said charging mechanism is transformed from said extended position to said retracted position, said charging mechanism is adapted to enable delivery of said pressurized and predetermined amount of compressed gas from at least one first predetermined position in said air-tight enclosure to at least one second predetermined position; d. an activation mechanism, adapted to entrain said flowable substance within said pressurized and predetermined amount of compressed gas.

Abstract: The present invention provides a method for delivering a substance to the nasal cavity of a subject in which drawing air from a mouthpiece triggers release of a substance to a subject's nasal cavities. The device comprises a container for containing the substance in fluid communication with a nosepiece, a valve with an active configuration and an inactive configuration, and a trigger mechanism to reconfigure the valve from its inactive configuration to its active configuration and vice versa. Drawing air from the mouthpiece, e.g., when the subject takes in air by mouth, activates the trigger mechanism, thereby reconfiguring the valve from its inactive configuration to its active configuration for a predetermined period of time and delivering the substance from the device to a nasal cavity of the subject.

Abstract: The present invention provides a method for delivering a substance to the nasal cavity of a subject in which drawing air from a mouthpiece triggers release of a substance to a subject's nasal cavities. The device comprises a container for containing the substance in fluid communication with a nosepiece, a valve with an active configuration and an inactive configuration, and a trigger mechanism to reconfigure the valve from its inactive configuration to its active configuration and vice versa. Drawing air from the mouthpiece, e.g., when the subject takes in air by mouth, activates the trigger mechanism, thereby reconfiguring the valve from its inactive configuration to its active configuration for a predetermined period of time and delivering the substance from the device to a nasal cavity of the subject.

Abstract: The present invention provides a method for delivering a substance to the nasal cavity of a subject in which drawing air from a mouthpiece triggers release of a substance to a subject's nasal cavities. The device comprises a container for containing the substance in fluid communication with a nosepiece, a valve with an active configuration and an inactive configuration, and a trigger mechanism to reconfigure the valve from its inactive configuration to its active configuration and vice versa. Drawing air from the mouthpiece, e.g., when the subject takes in air by mouth, activates the trigger mechanism, thereby reconfiguring the valve from its inactive configuration to its active configuration for a predetermined period of time and delivering the substance from the device to a nasal cavity of the subject.

Abstract: The present invention provides an air-intake device for delivering a substance to the nasal cavity of a subject which comprises: a container for containing the substance; a nosepiece and a mouthpiece extending from the device, for placement in proximity to the nose and mouth of the subject, respectively; a valve mechanically connectable to the container, with an active configuration and an inactive configuration; and, a trigger mechanism to reconfigure the valve from the active configuration to the inactive configuration, and vice versa. The trigger mechanism is activated by intaking air through the mouthpiece by the subject. Drawing air from the mouthpiece reconfigures the valve from its inactive configuration to its active configuration for a predetermined period of time and delivers the substance from the device to a nasal cavity of the subject.

Abstract: The present invention provides a method for delivering a substance to the nasal cavity of a subject in which drawing air from a mouthpiece triggers release of a substance to a subject's nasal cavities. The device comprises a container for containing the substance in fluid communication with a nosepiece, a valve with an active configuration and an inactive configuration, and a trigger mechanism to reconfigure the valve from its inactive configuration to its active configuration and vice versa. Drawing air from the mouthpiece, e.g., when the subject takes in air by mouth, activates the trigger mechanism, thereby reconfiguring the valve from its inactive configuration to its active configuration for a predetermined period of time and delivering the substance from the device to a nasal cavity of the subject.

Abstract: A drinking actuated device for delivering a substance to the nasal cavity of a subject, comprising: a container for containing the substance; a nosepiece extending from the device for placement in proximity to the nose of a subject, with the nosepiece in fluid communication with the container; a valve mechanically connectable to the container, characterized by an active configuration and an inactive configuration; and a trigger mechanism adapted to reversibly reconfigure the valve from the active configuration to the inactive configuration. The mouthpiece is fluidly connectable to by means of a tubule to a fluid reservoir containing a fluid. Drawing liquid from the reservoir into the mouth via the mouthpiece reconfigures the valve from the inactive configuration to the active configuration for a predetermined period of time in response to the pressure gradient generated by the suction applied by the subject to the tubule.

Abstract: It is one object of the present invention to provide an air-intake actuated device adapted for delivering a substance to a nasal cavity of a subject, comprising: a. a container for containing said substance; b. a nosepiece extending from said device for placement in proximity to a nose of said subject. c. a valve mechanically connectable to said container, characterized by an ACTIVE CONFIGURATION and an INACTIVE CONFIGURATION; and, d. a trigger mechanism adapted to reconfigure said valve from said ACTIVE CONFIGURATION to said INACTIVE CONFIGURATION, and vice versa; wherein said trigger mechanism is activated by means of said subject intaking air through said mouthpiece; further wherein said trigger mechanism is adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION for a predetermined period of time in response to said subject intake of air.