Abstract: Compositions that comprise protein conjugates comprising an NTF and a nontoxic fragment of a Clostridial neurotoxin. Vectors, host cells, and methods of use and making are also described. Pharmaceutical compositions comprising the protein conjugates described herein are used to provide neuroprotection and treat neurodegenerative diseases and neuron damage amongst other things.
Type:
Application
Filed:
April 3, 2020
Publication date:
May 26, 2022
Applicants:
TECHNICAL UNIVERSITY OF DENMARK, SIRA PHARMACEUTICALS INC.
Inventors:
Bjørn VOLDBORG, Stefan KOL, Johnny ARNSDORF, Shaji JOSEPH, Elizabeth BRUNK