Abstract: Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.
Type:
Grant
Filed:
August 31, 2017
Date of Patent:
February 22, 2022
Assignee:
SIRENAS LLC
Inventors:
Ippei Usui, Bryan Junn Lee, Steven Bruce Cohen, Venkat Rami Reddy Macherla, Jacob Neal Beverage, Chung-Mao Pan, Farhana Barmare, Eduardo Esquenazi
Abstract: Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat diseases such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.
Type:
Grant
Filed:
September 27, 2016
Date of Patent:
July 28, 2020
Assignee:
SIRENAS LLC
Inventors:
Oliver Booth Vining, Venkata Rami Reddy Macherla, Alexander Wayne Schammel, Ippei Usui, Jacob Neal Beverage, Elizabeth Paige Stout, Bryan Junn Lee, Steven Bruce Cohen, Eduardo Esquenazi
Abstract: Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.
Type:
Grant
Filed:
March 3, 2016
Date of Patent:
November 12, 2019
Assignee:
Sirenas LLC
Inventors:
Venkat Rami Reddy Macherla, Alexander Wayne Schammel, Ippei Usui, Elizabeth Paige Stout, Jacob Neal Beverage, Bryan Junn Lee, Steven Bruce Cohen
Abstract: Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.
Type:
Application
Filed:
August 31, 2017
Publication date:
July 11, 2019
Applicant:
SIRENAS LLC
Inventors:
Ippei USUI, Bryan Junn LEE, Steven Bruce COHEN, Venkat Rami Reddy MACHERLA, Jacob Neal BEVERAGE, Chung-Mao PAN, Farhana BARMARE, Eduardo ESQUENAZI
Abstract: Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.
Type:
Application
Filed:
March 3, 2016
Publication date:
January 19, 2017
Applicant:
Sirenas LLC
Inventors:
Venkat Rami Reddy MACHERLA, Alexander Wayne SCHAMMEL, Ippei USUI, Elizabeth Paige STOUT, Jacob Neal BEVERAGE, Bryan Junn LEE, Steven Bruce COHEN
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