Patents Assigned to Sirion Therapeutics, Inc.
  • Stable Aqueous Cyclosporin Compositions
    Publication number: 20090286718
    Abstract: An aqueous ophthalmic composition is disclosed. The composition may comprise a cyclosporin in an amount from about 0.001 to about 1%, glycerin, and purified water, wherein the composition is substantially free of NaCl and sodium bisulfite or sodium metabisulfite. The composition is useful for the treatment of ocular conditions.
    Type: Application
    Filed: November 17, 2008
    Publication date: November 19, 2009
    Applicant: SIRION THERAPEUTICS, INC.
    Inventor: William Francis STRINGER
  • MODULATORS OF OCULAR OXIDATIVE STRESS
    Publication number: 20090253745
    Abstract: Described herein are compounds, compositions and methods directed to the treatment of ophthalmic conditions characterized by oxidative stress or damage in a subject by reducing the reactive oxygen species in the subject. Also described herein are methods for reducing ophthalmic photooxidative damage in a subject.
    Type: Application
    Filed: November 26, 2008
    Publication date: October 8, 2009
    Applicant: SIRION THERAPEUTICS, INC.
    Inventors: Nathan L. MATA, Kim B. PHAN, Yun HAN, Tam V. BUI, Mustapha HADDACH
  • METHODS AND COMPOSITIONS FOR TREATING OPHTHALMIC CONDITIONS VIA MODULATION OF MEGALIN ACTIVITY
    Publication number: 20090098145
    Abstract: Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. Provided are methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.
    Type: Application
    Filed: June 22, 2007
    Publication date: April 16, 2009
    Applicant: Sirion Therapeutics, Inc.
    Inventors: Nathan L. MATA, Yun Han
  • METHODS AND COMPOUNDS FOR TREATING RETINOL-RELATED DISEASES
    Publication number: 20090088435
    Abstract: Compounds that reduce serum retinol levels are used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods, compounds, and compositions to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions.
    Type: Application
    Filed: September 15, 2008
    Publication date: April 2, 2009
    Applicant: SIRION THERAPEUTICS, INC.
    Inventors: Nathan L. MATA, Kim B. PHAN, Tam V. BUI, Mustapha HADDACH
  • Modulators of Retinol-Retinol Binding Protein (RBP)-Transthyretin (TTR) Complex Formation
    Publication number: 20090054532
    Abstract: Described herein are methods and compositions for the detection of transthyretin (TTR), retinol binding protein (RBP) and retinol complex formation. The methods and compositions described herein also provide for the screening of modulators of retinol-RBP-TTR complex formation. Furthermore, the methods and compositions provide for therapeutic agents for the treatment and/or prevention of age-related macular degeneration and/or dystrophies.
    Type: Application
    Filed: August 11, 2008
    Publication date: February 26, 2009
    Applicant: SIRION THERAPEUTICS, INC.
    Inventors: Nathan L. Mata, Yun Han, Kenneth Widder, Jay Lichter
  • Modulators of retinol-retinol binding protein (RBP)-transthyretin (TTR) complex formation
    Patent number: 7432307
    Abstract: Described herein are methods and compositions for the detection of transthyretin (TTR), retinol binding protein (RBP) and retinol complex formation. The methods and compositions described herein also provide for the screening of modulators of retinol-RBP-TTR complex formation. Furthermore, the methods and compositions provide for therapeutic agents for the treatment and/or prevention of age-related macular degeneration and/or dystrophies.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: October 7, 2008
    Assignee: Sirion Therapeutics, Inc.
    Inventors: Nathan L. Mata, Kenneth Widder, Jay Lichter