Abstract: Presented are automatic end-of-arm tool changing devices, methods for making/using such tool changing devices, and automated robotic systems with such tool changing devices. A tool changing device for an automated robotic system includes a quick-change (QC) interlock subassembly that attaches to an end effector. The QC subassembly includes a housing, one or more locking pins movable on the QC housing, and one or more anchor pins projecting from the QC housing. A finger block (FB) subassembly, which performs a task on a target object, includes a housing, a robot tool mounted to the FB housing, and one or more key slots and one or more pin holes in the FB housing. Each key slot receives an anchor pin; once the anchor pin is slid to a locking end of the key slot, each locking pin automatically slides into a pin hole to thereby lock together the QC and FB subassemblies.