Patent number: 7964578
Abstract: This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including cholesterol, folate, galactose, galactosamine, N-acetyl galactosamine, PEG, phospholipid, peptide and human serum albumin (HSA) derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones, nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers.
Type:
Grant
Filed:
October 16, 2008
Date of Patent:
June 21, 2011
Assignee:
Sirna Therapeutics, Inc.
Inventors:
Chandra Vargeese, Peter Haeberli, Weimin Wang, Tongqian Chen