Patents Assigned to SIRONAX LTD
  • Cyclic ureas
    Patent number: 12662469
    Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: June 23, 2026
    Assignee: SIRONAX LTD
    Inventors: Zhiyuan Zhang, Yaning Su, Jianguang Han, Hanying Ruan, Ying Li, Guozheng Wang, Wendong Liu, Chong Zhang, Leiming Liang
  • Difluoro phenyl amide RIP1 inhibitor
    Patent number: 12129221
    Abstract: The disclosed compounds inhibit cellular necrosis, and include corresponding sulfonamides, prodrugs and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: October 29, 2024
    Assignee: SIRONAX LTD
    Inventors: Zhiyuan Zhang, Yaning Su, Yi Yang, Guozheng Wang, Wendong Liu, Yongfen Ma, Yan Ren
  • Cyclic Ureas
    Publication number: 20210292305
    Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
    Type: Application
    Filed: May 19, 2021
    Publication date: September 23, 2021
    Applicant: SIRONAX LTD
    Inventors: Zhiyuan Zhang, Yaning Su, Jianguang Han, Hanying Ruan, Ying Li, Guozheng Wang, Wendong Liu, Chong Zhang, Leiming Liang
  • RIP1 Inhibitors
    Publication number: 20210284598
    Abstract: The invention provides amides that inhibit cellular necrosis including corresponding sulfonamides, prodrugs and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
    Type: Application
    Filed: May 19, 2021
    Publication date: September 16, 2021
    Applicant: SIRONAX LTD
    Inventors: Zhiyuan Zhang, Yaning Su, Yi Yang, Guozheng Wang, Wendong Liu, Yongfen Ma, Yan Ren