Patents Assigned to Sirs-Lab GmbH
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Patent number: 8481262Abstract: The invention relates to a method for separating and/or enriching prokaryotic DNA, comprising the following steps: a) contacting of at least one prokaryotic DNA that is in solution with a protein that bonds specifically to prokaryotic DNA, the protein being 25%-35% homologous with the wild-type CGPB protein, thus forming a protein-DNA complex; and b) separation of the complex. The invention also relates to a kit for carrying out said method.Type: GrantFiled: March 2, 2005Date of Patent: July 9, 2013Assignee: SIRS-Lab GmbHInventors: Karl-Hermann Schmidt, Eberhard Straube, Stefan Russwurm, Hans-Peter Deigner, Svea Sachse, Marc Lehmann
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Patent number: 8476200Abstract: The present invention relates to the use of gene expression profiles obtained in vitro from patient samples for differentiating between the non-infectious and infectious causes of multiple organ failure. The invention also relates to a method for measuring gene expression profiles in vitro and the use of said gene expression profiles and/or of the probes used therein for screening active substances against the non-infectious and/or infectious causes of multiple organ failure.Type: GrantFiled: August 18, 2005Date of Patent: July 2, 2013Assignee: SIRS-Lab GmbHInventors: Stefan Russwurm, Konrad Reinhart
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Patent number: 8338099Abstract: The present invention relates to reference genes, primers, and probes for the normalization of gene expression analysis data from blood samples of a patient. The invention further relates to a method for the normalization of gene expression analysis data with the aid of reference genes, primers, or probes.Type: GrantFiled: February 28, 2008Date of Patent: December 25, 2012Assignee: SIRS-Lab GmbHInventors: Stefan Russwurm, Hans-Peter Saluz, Hans-Peter Deigner
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Patent number: 8288115Abstract: A method is described for enriching procaryotic DNA, said method including the steps of contacting at least one procaryotic DNA with at least one protein or polypeptide which is capable of specifically binding to non-methylated CpG motifs, and separating the protein/polypeptide-DNA complex. Moreover, the application relates to a kit for carrying out said method.Type: GrantFiled: October 5, 2011Date of Patent: October 16, 2012Assignee: SIRS-Lab GmbHInventors: Karl-Hermann Schmidt, Eberhard Straube, Stefan Russwurm
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Patent number: 8236496Abstract: The present invention relates to the use of gene activity markers for classification of patients suffering from infectious and non-infectious multiple organ failure, respectively. The present invention in particular relates to gene activity markers for classification of patients as “not infected without multiple organ failure” or as “not suffering from infectious multiple organ failure” or as “suffering from infectious multiple organ failure”, the gene activity markers being polynucleotides selected from the group consisting of: SEQ ID I.1, SEQ ID I.2, SEQ ID I.3, SEQ ID I.4, SEQ ID I.5, SEQ ID I.6, SEQ ID I.7, SEQ ID I.8 and SEQ ID I.9 or partial sequences thereof.Type: GrantFiled: March 16, 2006Date of Patent: August 7, 2012Assignee: SIRS-Lab GmbHInventors: Stefan Russwurm, Konrad Reinhart
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Publication number: 20120040363Abstract: A method is described for enriching procaryotic DNA, said method including the steps of contacting at least one procaryotic DNA with at least one protein or polypeptide which is capable of specifically binding to non-methylated CpG motifs, and separating the protein/polypeptide-DNA complex. Moreover, the application relates to a kit for carrying out said method.Type: ApplicationFiled: October 5, 2011Publication date: February 16, 2012Applicant: SIRS-LAB GMBHInventors: Karl-Hermann SCHMIDT, Eberhard STRAUBE, Stefan RUSSWURM
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Patent number: 8062854Abstract: A method is described for enriching procaryotic DNA, said method including the steps of contacting at least one procaryotic DNA with at least one protein or polypeptide which is capable of specifically binding to non-methylated CpG motifs, and separating the protein/polypeptide-DNA complex. Moreover, the application relates to a kit for carrying out said method.Type: GrantFiled: August 8, 2003Date of Patent: November 22, 2011Assignee: SIRS-Lab GmbHInventors: Karl-Hermann Schmidt, Eberhard Straube, Stefan Russwurm
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Publication number: 20110076685Abstract: The present invention relates to the use of defined polynucleotides to form at least one multi-gene biomarker for producing a multiplex assay as a tool for in vitro detection and/or early detection and/or differentiation and/or progress monitoring and/or evaluation of pathophysiological conditions of a patient, the pathophysiological condition selected from the group consisting of: SIRS, sepsis and its degrees of severity; sepsis-like conditions, septic shock, bacteremia, infective/non-infectious multiorgan failure, early detection of these conditions; focus control, control of surgical rehabilitation of the infection focus; responders/non-responders for a specific therapy, treatment monitoring; distinction between infectious and non-infectious etiology of systemic reactions of the organism, such as SIRS, sepsis, postoperative complications, chronic and/or acute organ dysfunction, shock response, inflammatory response and/or trauma.Type: ApplicationFiled: September 23, 2010Publication date: March 31, 2011Applicant: SIRS-LAB GMBHInventors: Eva Moeller, Britta Wlotzka, Andriy Ruryk
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Publication number: 20100184608Abstract: The present invention relates to reference genes, primers, and probes for the normalization of gene expression analysis data from blood samples of a patient. The invention further relates to a method for the normalization of gene expression analysis data with the aid of reference genes, primers, or probes.Type: ApplicationFiled: February 28, 2008Publication date: July 22, 2010Applicant: SIRS-Lab GmbHInventors: Stefan Russwurm, Hans-Peter Saluz, Hans-Peter Deigner
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Publication number: 20100152053Abstract: The present invention relates to the use of gene expression profiles, obtained in vitro from a patient sample, for detecting any postoperative tissue incompatibility reactions following a liver transplantation, wherein in patients the gene activity of a plurality of specific genes relevant to a liver transplantation is determined in a patient sample, and the specific genes and/or gene fragments for monitoring of postoperative states are selected from the group consisting of: SEQ-ID No. 1 to SEQ-ID No. 532, these preferably being subdivided into several clusters.Type: ApplicationFiled: April 11, 2007Publication date: June 17, 2010Applicant: SIRS-LAB GMBHInventor: Stefan Russwurm
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Publication number: 20100086909Abstract: The invention relates to the use of gene expression profiles, obtained in vitro from a patient sample, for the generation of criteria for the prediction of an individual course of disease in sepsis. The invention is further of use for determining the probability of survival in sepsis, the assessment of the course of disease in sepsis during treatment and for the classification of sepsis patients.Type: ApplicationFiled: January 14, 2005Publication date: April 8, 2010Applicant: SIRS-LAB GMBHInventors: Stefan Russwurm, Hans-Peter Deigner
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Publication number: 20090325152Abstract: The present invention relates to the use of gene activity markers for classification of patients suffering from infectious and non-infectious multiple organ failure, respectively. The present invention in particular relates to gene activity markers for classification of patients as “not infected without multiple organ failure” or as “not suffering from infectious multiple organ failure” or as “suffering from infectious multiple organ failure”, the gene activity markers being polynucleotides selected from the group consisting of: SEQ ID 1.1, SEQ ID 1.2, SEQ ID 1.3, SEQ ID 1.4, SEQ ID 1.5, SEQ ID 1.6, SEQ ID 1.7, SEQ ID 1.8 and SEQ ID 1.9 or partial sequences thereof.Type: ApplicationFiled: March 16, 2006Publication date: December 31, 2009Applicant: SIRS-LAB GMBHInventors: Stefan Russwurm, Konrad Reinhart
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Publication number: 20080070235Abstract: The present invention relates to a method for in vitro detection of SIRS, sepsis and/or sepsis-like conditions. This method renders the evaluation of the severity and/or the therapeutic progress of sepsis and severe infections, in particular sepsis-like systemic infections possible. Further, the present invention relates to the use of recombinantly or synthetically prepared nucleic acid sequences or peptide sequences derived therefrom as calibrator in sepsis assays and/or for the evaluation of the effect and the toxicity during screening of the active agents and/or the preparation of therapeutics for the prevention and treatment of SIRS, sepsis, sepsis-like systemic inflammatory conditions and sepsis-like systemic infections.Type: ApplicationFiled: March 31, 2004Publication date: March 20, 2008Applicant: SIRS-Lab GMBHInventors: Stefan Russwurm, Konrad Reinhart, Hans-Peter Saluz, Eberhard Straube, Peter Zipfel, Hans-Peter Deigner
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Patent number: 7301043Abstract: Compounds for determining the activity of phospholipase A2, are described herein, and include embodiments having formula (1) wherein L1 is derived from an ether (R1—OR2)m, wherein R1 and R2 are independently selected and are derived from a hydrocarbon having 1 to 12 carbon atoms, with m being an integer from 1 to 4, or from a hydrocarbon R having 1 to 20 carbon atoms; F is unsubstituted or substituted pyrene as a flouraphore; Q is a quencher, and L2 is C(O)-L1 or C(O)-L1-NH, wherein L1 is as defined above. These compounds may be used to determine the activity of phospholipase A2, in particular PAF-AH.Type: GrantFiled: October 23, 2002Date of Patent: November 27, 2007Assignee: Sirs-Lab GmbHInventors: Hans-Peter Deigner, Stefan Russwurm, Ralf Kinscherf, Wolfgang Lösche