Patents Assigned to Sirtex Medical Limited
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Patent number: 11241362Abstract: A device for transferring a toxic substance from a dispensing vessel to at least one receiving vessel comprising: (i) a receiving portion arranged to receive a dispensing vessel containing a toxic substance; and (ii) a transfer apparatus having a first infusion line adapted for fluid communication with the dispensing vessel to transfer a carrier fluid into said vessel and a second infusion line having one end adapted for fluid communication to withdraw and transfer the carrier fluid and the toxic substance from the dispensing vessel and the other end of the second infusion line arranged to connect with the at least one receiving vessel.Type: GrantFiled: September 30, 2015Date of Patent: February 8, 2022Assignee: SIRTEX MEDICAL LIMITEDInventors: Brendon Van Den Berg, Gilman Wong
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Patent number: 11097021Abstract: The invention relates to a particulate material having a diameter in the range of from 5 to 200 microns comprising polymeric matrix stably incorporated radionuclide, processes for its production and method of radiation therapy utilising the particulate material.Type: GrantFiled: February 20, 2019Date of Patent: August 24, 2021Assignee: Sirtex Medical LimitedInventor: Bruce Nathaniel Gray
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Patent number: 10849900Abstract: A method of treating cancer in a patient comprising administering to the patient an a systemic chemotherapeutic drug regime in combination with radioactively doped particle, characterised in that the two therapies when introduced into the patient have an improved anticancer effect.Type: GrantFiled: January 23, 2015Date of Patent: December 1, 2020Assignee: Sirtex Medical LimitedInventors: David Cade, Michael Tapner
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Patent number: 10232063Abstract: Accordingly, the present invention provides a method of treating lung neoplasia in a subject in need of treatment, by subjecting the patient to SIRT.Type: GrantFiled: July 7, 2015Date of Patent: March 19, 2019Assignee: Sirtex Medical LimitedInventors: Jens Ricke, Holger Amthauer, Oliver Grober
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Publication number: 20170304151Abstract: A device for transferring a toxic substance from a dispensing vessel to at least one receiving vessel comprising: (i) a receiving portion arranged to receive a dispensing vessel containing a toxic substance; and (ii) a transfer apparatus having a first infusion line adapted for fluid communication with the dispensing vessel to transfer a carrier fluid into said vessel and a second infusion line having one end adapted for fluid communication to withdraw and transfer the carrier fluid and the toxic substance from the dispensing vessel and the other end of the second infusion line arranged to connect with the at least one receiving vessel.Type: ApplicationFiled: September 30, 2015Publication date: October 26, 2017Applicant: SIRTEX MEDICAL LIMITEDInventors: Brendon VAN DEN BERG, Gilman WONG
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Publication number: 20170000795Abstract: A method of treating cancer in a patient comprising administering to the patient an a systemic chemotherapeutic drug regime in combination with radioactively doped particle, characterised in that the two therapies when introduced into the patient have an improved anticancer effect.Type: ApplicationFiled: January 23, 2015Publication date: January 5, 2017Applicant: SIRTEX MEDICAL LIMITEDInventors: David Cade, Michael Tapner
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Publication number: 20140249351Abstract: A microparticle composition(s) comprising nanomagnetic particles and a matrix, wherein said microparticle composition(s) have a least one of the following properties: (a) a VAR of at least about 1 Watts/cm3 subject to appropriate field conditions; (b) a density of about 2.7 or less: or (c) a size of about 100 nm to about 200 microns.Type: ApplicationFiled: May 15, 2014Publication date: September 4, 2014Applicant: Sirtex Medical LimitedInventors: Stephen Keith Jones, Katrina Francis Rutherford, Andrew John Ruys, Bruce Nathaniel Gray
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Publication number: 20140099255Abstract: The invention relates to a particulate material having a diameter in the range of from 5 to 200 microns comprising polymeric matrix and stably incorporated radionuclide, processes for its production and a method of radiation therapy utilising the particulate material.Type: ApplicationFiled: August 16, 2013Publication date: April 10, 2014Applicant: Sirtex Medical LimitedInventor: Bruce Nathaniel Gray
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Publication number: 20100215571Abstract: The invention relates to a particulate material having a diameter in the range of from 5 to 200 microns comprising polymeric matrix and stably incorporated radionuclide, processes for its production and a method of radiation therapy utilising the particulate material.Type: ApplicationFiled: February 25, 2010Publication date: August 26, 2010Applicant: SIRTEX MEDICAL LIMITEDInventor: Bruce Nathaniel Gray
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Publication number: 20070253898Abstract: The invention relates to a particulate material having a diameter in the range of from 5 to 200 microns comprising polymeric matrix and stably incorporated radionuclide, processes for its production and a method of radiation therapy utilising the particulate material.Type: ApplicationFiled: May 2, 2007Publication date: November 1, 2007Applicant: Sirtex Medical LimitedInventor: Bruce GRAY
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Patent number: 7150867Abstract: This invention relates to a particulate material comprising an inorganic low density, radiation tolerant core coated with a radionuclide, processes for its production and a method of radiation therapy utilizing the particulate material.Type: GrantFiled: June 17, 2002Date of Patent: December 19, 2006Assignee: Sirtex Medical LimitedInventors: Andrew John Ruys, Bruce Andrew Gray
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Publication number: 20060177373Abstract: The invention relates to a particulate material consisting of a low density radiation-tolerant glass and a radionuclide incorporated into the low density glass or coated on the low density glass, the glass having a density of less than 2.5 g/cm.sup.3, processes for its production and a method of radiation therapy utilising the patentable material.Type: ApplicationFiled: July 27, 2005Publication date: August 10, 2006Applicant: Sirtex Medical LimitedInventors: Andrew Ruys, Bruce Gray
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Patent number: 6998105Abstract: The invention relates to a particulate material consisting of a low density radiation-tolerant glass and a radionuclide incorporated into the low density glass or coated on the low density glass, the glass having a density of less than 2.5 g/cm3, processes for its production and a method of radiation therapy utilising the patentable material.Type: GrantFiled: June 17, 2002Date of Patent: February 14, 2006Assignee: Sirtex Medical LimitedInventors: Andrew John Ruys, Bruce Nathaniel Gray
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Publication number: 20040220135Abstract: The present invention concerns an unexpected synergistic combination of known antineoplastic therapies, which provides unexpectedly greater efficacy than either therapy alone in the treatment of neoplasia. Accordingly, the present invention provides a method that has utility in the treatment of various forms of cancer and tumours, but particularly in the treatment of brain and colorectal liver metastases and more specifically in the treatment of primary and secondary cancer of the liver. It is to be understood that the selective internal radiation therapies described herein should not be limited to radioactive microparticles, but may be extended to any radioactive particles that are suitable for use in the treatment methods described herein.Type: ApplicationFiled: April 30, 2003Publication date: November 4, 2004Applicant: SIRTEX MEDICAL LIMITEDInventor: Bruce Nathaniel Gray
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Patent number: 6599234Abstract: A magnetic material having a magnetic heating efficiency of at least 4.5×10−8 J.m/A.g in a cyclic magnetic field where the product of the amplitude and frequency of the applied field is less than or equal to 5×108 A/m.s, and the frequency of the applied filed is at least 20 kHz. The ideal magnetic material is characterized by a perfectly rectangular hysteresis loop, i.e. loop squareness of 1, with coercivity of 25 kA/m or less and high saturation magnetization. Preferably the magnetic material has a predominately cubic magnetic crystalline anisotropy. Preferably the magnetic material is a substituted magnetite (Fe3O4) or &ggr;-ferric oxide (&ggr;Fe2O3) crystalline lattice in which some of the iron atoms in that crystalline lattice have been substituted for one or more alternate metals atoms. Desirably, the metal atom is a member of the group: cobalt, zinc, nickel, manganese, magnesium, copper, chromium, gallium, cadmium.Type: GrantFiled: December 20, 2001Date of Patent: July 29, 2003Assignee: Sirtex Medical LimitedInventors: Bruce Nathaniel Gray, Raffaele Cammarano, Stephen Keith Jones
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Patent number: 6565887Abstract: A method for site specific treatment of diseased tissue in a patient, comprising the steps of: (i) selecting at least a magnetic material which has a magnetic heating efficiency of at least about 4.5×10−8 J.m./A.g, when magnetic field conditions are equal to or less than about 7.5×107 A/s; (ii) delivering the magnetic material to diseased tissue in a patient; and (iii) exposing the magnetic material in the patient to a linear alternating magnetic field with a frequency of greater than about 10 kHz and a field strength such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5×107 A/s to generate hysteresis heat in the diseased tissue.Type: GrantFiled: May 12, 2000Date of Patent: May 20, 2003Assignee: Sirtex Medical LimitedInventors: Bruce Nathaniel Gray, Stephen Keith Jones
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Patent number: 6537518Abstract: A particulate material comprises hollow or cup-shaped ceramic microspheres having a diameter in the range of from 5 to 200 microns, the microspheres being formed from a base material comprising greater than 70% by weight of yttria or another yttrium-containing compound together with one or more compounds selected from the group consisting of alumina or another aluminium-containing compound, zirconia or another zirconium-containing compound, and silica or another silicon-containing compound. The particulate material may comprise a beta-radiation emitting radionuclide ytrrium-90, and be used in selective internal radiation therapy (SIRT) of various forms of cancer and tumors.Type: GrantFiled: August 16, 2000Date of Patent: March 25, 2003Assignee: Sirtex Medical LimitedInventor: Bruce Nathaniel Gray
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Patent number: 6258338Abstract: A particulate material which comprises hollow or cup-shaped ceramic microspheres having a diameter in the range of from 5 to 200 microns. The material may comprise a beta- or gamma-emitting radionuclide and be used in selective internal radiation therapy (SIRT) of various forms of cancer and tumours.Type: GrantFiled: October 23, 1998Date of Patent: July 10, 2001Assignee: Sirtex Medical LimitedInventor: Bruce Nathaniel Gray
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Patent number: 6167313Abstract: A method for site specific treatment of diseased tissue in a patient, comprising the steps of: (i) selecting at least a magnetic material which has a magnetic heating efficiency of at least about 4.5.times.10.sup.-8 J.m./A.g, when magnetic field conditions are equal to or less than about 7.5.times.10.sup.7 A/s; (ii) delivering the magnetic material to diseased tissue in a patient; and (iii) exposing the magnetic material in the patient to a linear alternating magnetic field with a frequency of greater than about 10 kHz and a field strength such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5.times.10.sup.7 A/s to generate hysteresis heat in the diseased tissue.Type: GrantFiled: November 9, 1998Date of Patent: December 26, 2000Assignee: Sirtex Medical LimitedInventors: Bruce Nathaniel Gray, Stephen Keith Jones