Abstract: Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
Type:
Application
Filed:
December 8, 2009
Publication date:
December 29, 2011
Applicant:
Sirtis Pharmaceuticals, Inc.
Inventors:
Chi B. Vu, Lauren Mcpherson, Pui Yee Ng, Charles Blum
Abstract: Provided herein are novel sirtuin-modulating compounds Structural Formula (I): and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
Type:
Application
Filed:
November 7, 2008
Publication date:
January 13, 2011
Applicant:
Sirtis Pharmaceuticals, Inc.
Inventors:
Chi B. Vu, Christopher Oalmann, Robert B. Perni, Jeremy S. Disch, Bruce Szczepankiewicz, Giovanna Gualtieri, Rebecca L. Casaubon
Abstract: Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
Type:
Application
Filed:
August 4, 2006
Publication date:
February 15, 2007
Applicant:
Sirtis Pharmaceuticals, Inc.
Inventors:
Joseph Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi Vu, Pui Ng, Jeremy Disch, Thomas Salzmann, David Armistead