Abstract: A bacteria-mediated platform that uses invasive, non-pathogenic bacteria to both produce and intracellularly deliver antibodies, antibody derivatives, and proteins/polypeptides to targeted eukaryotic cells and tissues. The bacteria can contain a prokaryotic expression cassette encoding the protein cargo.
Type:
Application
Filed:
June 2, 2022
Publication date:
December 5, 2024
Applicant:
SiVEC Biotechnologies, Inc.
Inventors:
Lyndsey M Linke, Ashley B Williams, Darcy Mora, Madeline Cox, Timothy Enroth