Abstract: A dynamic, real-time, genomics decision support and simulation system is disclosed. The system receives individual search criteria associated with an individual, and generates and formats a digital file including the individual search criteria into a format suitable for communication, storage, synthesis, analysis, or a combination thereof, by components of the system. The system compares the individual search criteria from the formatted digital file to information from a reference database. Based on the comparing, the system may identify a potential relationship between the individual search criteria and a disease or condition identified in the information from the reference database. The system may present the potential match, along with an analysis relating to the relationship, on a visualization interface on a device associated with the individual.