Patents Assigned to SK&F Lab Co.
  • Use of N-cyano-N'-methyl-N"-[2-(5-methyl-4-imidazolylmethyldithio)ethyl]guanidi ne in the preparation of cimetidine
    Patent number: 4447621
    Abstract: A process for preparing cimetidine by sulfur extrusion from N-cyano-N'-methyl-N"-[2-(5-methyl-4-imidazolylmethyldithio)ethyl]guanidine .
    Type: Grant
    Filed: October 21, 1982
    Date of Patent: May 8, 1984
    Assignee: SK&F Lab Co.
    Inventors: Clifford S. Labaw, George R. Wellman
  • Process for preparing an imidazole derivative
    Patent number: 4381395
    Abstract: This invention relates to new processes for preparing an imidazole derivative, i.e. cimetidine, by (1) reacting an imidazolylmethylthioethylamine with an amidine or (2) reacting a N-cyano-N'-imidazolylmethylthioethyl formamidine with methylamine or (3) reacting a N-methyl-N'-imidazolylmethylthioethyl formamidine with cyanamide.
    Type: Grant
    Filed: April 3, 1981
    Date of Patent: April 26, 1983
    Assignee: SK & F Lab Co.
    Inventors: Tsutomu Teraji, Yoshiharu Nakai, Graham J. Durant
  • Disulfide intermediate for cimetidine
    Patent number: 4374996
    Abstract: A process for preparing cimetidine by sulfur extrusion from N-cyano-N'-methyl-N"-[2-(5-methyl-4-imidazolylmethyldithio)ethyl]guanidine .
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: February 22, 1983
    Assignee: SK & F Lab Co.
    Inventors: Clifford S. Labaw, George R. Wellman
  • Benzyl 5-methyl-4-imidazolecarboxylate
    Patent number: 4374252
    Abstract: A process for the preparation of 5-methyl-4-imidazolecarboxylic acid esters from acetoacetic acid esters. The products of this process are useful as intermediates for preparing cimetidine.
    Type: Grant
    Filed: December 10, 1981
    Date of Patent: February 15, 1983
    Assignee: SK&F Lab Co.
    Inventors: Harold Graboyes, Thomas J. Kasper, Praful D. Vaidya
  • Process for preparing 5-methyl-4-imidazolecarboxylic acid esters
    Patent number: 4328349
    Abstract: A process for the preparation of 5-methyl-4-imidazolecarboxylic acid esters from acetoacetic acid esters. The products of this process are useful as intermediates for preparing cimetidine.
    Type: Grant
    Filed: October 8, 1980
    Date of Patent: May 4, 1982
    Assignee: SK&F Lab Co.
    Inventors: Harold Graboyes, Thomas J. Kasper, Praful D. Vaidya
  • Imidazolemethylphosphonium salts
    Patent number: 4267337
    Abstract: A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)methylimidazole compounds is disclosed.
    Type: Grant
    Filed: December 12, 1979
    Date of Patent: May 12, 1981
    Assignee: SK&F Lab Co.
    Inventors: Joseph J. Lewis, Robert L. Webb
  • Process for preparing 4-substituted imidazole compounds
    Patent number: 4215217
    Abstract: A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)-methylimidazole compounds is disclosed.
    Type: Grant
    Filed: June 14, 1978
    Date of Patent: July 29, 1980
    Assignee: SK&F Lab Co.
    Inventors: Joseph J. Lewis, Robert L. Webb
  • Process for preparing new imidazolemethylphosphonium salts
    Patent number: 4163858
    Abstract: New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H.sub.2 antagonists. This invention concerns the preparation of imidazolemethylphosphonium salts having no substituent at the 2-position by heating the compounds referred to above.
    Type: Grant
    Filed: March 8, 1978
    Date of Patent: August 7, 1979
    Assignee: SK&F Lab Co.
    Inventors: Clifford S. Labaw, Robert L. Webb, George R. Wellman
  • Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts
    Patent number: 4139708
    Abstract: New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H.sub.2 antagonists.
    Type: Grant
    Filed: March 8, 1978
    Date of Patent: February 13, 1979
    Assignee: SK&F Lab Co.
    Inventors: Clifford S. Labaw, Robert L. Webb, George R. Wellman
  • Process for preparing 4-substituted imidazole compounds
    Patent number: 4119781
    Abstract: A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)methylimidazole compounds is disclosed.
    Type: Grant
    Filed: February 22, 1977
    Date of Patent: October 10, 1978
    Assignee: SK&F Lab Co.
    Inventors: Joseph J. Lewis, Robert L. Webb
  • Process for preparing 4-(hydroxymethyl)imidazole compounds
    Patent number: 4063023
    Abstract: An improved process for the preparation of 4-(hydroxymethyl)imidazoles by reducing 4-imidazolecarboxylic acid esters using an alkali metal or calcium in liquid ammonia with an additional proton source provided during the reaction or upon workup.
    Type: Grant
    Filed: May 27, 1976
    Date of Patent: December 13, 1977
    Assignee: SK&F Lab Co.
    Inventors: Elvin L. Anderson, Wilford L. Mendelson, George R. Wellman