Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: A method for path planning for a machine to traverse an area includes calculating a spline trajectory based on a plurality of control points of a first path. A subset of the plurality of control points having an equal step is selected. A direction of the normal to the spline trajectory for each of the selected points is determined. Control points within the subset that are a solution to a second order cone programming class optimization problem along each normal to the spline trajectory are searched for and the spline trajectory is extended to a border of the area to create a second path adjacent to the first path based on the control points. The optimization problem can minimize the weighted sum of the average curvature at junction points of elementary sections of the spline trajectory and/or the average width overlap of adjacent paths.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: Methods for training statistical models for the bandgap and energy dispersion of materials as a function of an applied strain, as well as uses of these trained statistical models for elastic strain engineering of materials, are described.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: The invention discloses design of the open-type dynamically harmonized trap directly incorporated into the body of vacuum chamber of Fourier transform ion cyclotron resonance mass analyzer. The proposed trap provides ultra-high resolution of the mass spectrometer as well as improves performance of the instrument, increases pumping rate (accelerates evacuation), eliminates necessity in vacuum feed-through, and increases maximum trap resolution limit at a fixed magnetic field.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.