Abstract: The present disclosure provides a compound comprising a modified tetracycline derivative, covalently coupled through a linker to a low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases, wherein the modified tetracycline derivative is optionally defined by the following formula:
Type:
Grant
Filed:
March 14, 2023
Date of Patent:
April 9, 2024
Assignees:
Skybio LLC, Consejo Nacional de Investigaciones Cientificas y Ténicas (Conicet), Universidad Nacional de Tucumán, Universidad de Buenos Aires, Sistema Provincial De Salud De Tucumán
Inventors:
Oscar José Varela, Rosana Nieves Chehín, Cesar Luis Ávila, Sergio Benjamin Socías, Diego Ploper, Esteban Vera Pingitore, Analía Silvina Chaves, Martin Luong, Verónica Elena Manzano, Rodrigo Hernán Tomas Grau, Maria Florencia González Lizárraga, Adriana Andrea Kolender, Agustín Osvaldo Pernicone