Abstract: The present invention provides a polynucleotide and recombinant AAV encoding human alpha galactosidase A. The present invention also provides a method of treating Fabry disease comprising administering the recombinant AAV to a subject in need thereof.

Abstract: A charging connector for an electric vehicle is disclosed. The system comprises a power supply electrically connected to the charging connector by a cable. The charging connector is configured to charge the electric vehicle. The charging connector is further configured to eject from the electric vehicle when the electric vehicle reaches a suitable threshold.

Abstract: The present invention relates to a modified adeno-associated virus (AAV) capsid polypeptide and a novel recombinant adeno-associated virus (rAAV) comprising the modified AAV capsid polypeptide for delivering the gene product for the therapy. The present invention also relates to a pharmaceutical composition comprising the rAAV of the present invention, and a method of treating a retinal disease comprising the administration of the rAAV or the pharmaceutical composition of the present invention to an eye of a subject in need thereof.

Abstract: A computer-implemented method and system manages and processes outstanding invoices within various accounting software applications. The method includes analyzing a web page to identify a unique invoice identifier (e.g., within the web page's URL or a user interface element of the web page), obtaining additional invoice information from the accounting system based on the unique invoice identifier, and displaying this information in a user-friendly interface. A web browser plugin facilitates real-time data synchronization and payment processing by interacting with the accounting system through an API. The system streamlines the payment process by reducing the number of steps required, improving the efficiency and accuracy of financial transactions. The system is designed to be compatible with multiple accounting systems and web browsers, ensuring broad applicability and ease of use.

Abstract: Disclosed is a method for controlling cleaning at least a portion of a building facade (104a). A multi-dimensional map of a facade (104a) is cleaned from an elevator platform (200) of an elevator system is received. According to the map, an ordered sequence of instructions is determined. The instructions comprise robotic arm instructions and elevator platform instructions that are temporally intertwined to execute a cleaning pattern covering at least part of facade (104a). The robotic arm instructions are forwarded to control one or more robotic arms (206) and the elevator platform instructions are forwarded to control the elevation of the elevator platform (200). A corresponding device (221, 213) and non-transient memory (223), and a system having the device, are also disclosed.

Abstract: The present invention provides a polynucleotide and vector, in particular AAV vector, encoding a nanobody against VEGF. The present invention also provides a method of treating a disease associated with VEGF, such as the overexpression of VEGF, e.g., Wet-AMD and DME comprising administering the vector by, e.g., intravitreal injection to provide stable expression of the nanobody in eyes.

Abstract: Embodiments of a modular sign system with a wireless backplane and related methods are generally described herein. Many embodiments include a sign system. In some embodiments, the sign system can comprise a plurality of units, a wireless communication system configured to transfer information between the plurality of units, and a control device configured to transmit information to at least one unit of the plurality of units. In many embodiments, each unit of the plurality of units comprises a display of a plurality displays, a controller of a plurality of controllers, and a transceiver of a plurality of transceivers. Other embodiments may be described and claimed.

Abstract: A method and system for detecting a relevant subject entity across different databases.

Abstract: A system and method for resolving entities between databases. A method includes: resolving an entity between a first database and a second database, wherein the entity is resolved such that respective instances of the entity in the first database and the second database are determined as each uniquely identifying the same entity, wherein resolving the entity further comprises applying resolution rules requiring at least matching a plurality of features between respective instances of the entity; and joining the first database and the second database when the entity has been resolved between the first database and the second database.

Abstract: A method and system for detecting relevant potential participating entities across different databases.

Abstract: A system and method for identifying second degree connections between entities represented in different databases.

Abstract: A fixed wireless access radio is disclosed that is compact, light and low power for street level mounting, operates at 100 Mb/s or higher at ranges of 300 m or longer in obstructed LOS conditions with low latencies of 5 ms or less, can support PTP and PMP topologies, uses radio spectrum resources efficiently and does not require precise physical antenna alignment.

Abstract: A method for price optimization for a product or service at a store using machine learning is disclosed. The method includes determining a price through a reaction model, positioning model, and a forecast model. The reaction model includes determining the probabilities of a competitors' pricing reaction due to the store's price changes. The positioning model includes determining conditional probabilities for attaining an objective and/or sub-objective based on store and competitor's data. The conditional probabilities are used for generating a price proposal for achieving the objective and/or sub-objective. The forecast model provides a forecast for factors such as volume sale using machine learning.

Abstract: A system and method of collecting and disposing of fluid during a medical procedure. Fluid is drawn from a fluid source into a first reservoir in communication with a vacuum source. The fluid passes through an open fluid transfer valve into a second reservoir in communication with the vacuum source. While the fluid continues to be drawn into the first reservoir, the fluid transfer valve is closed after a predetermined volume of the fluid passes into the second reservoir. The fluid collected in the second reservoir is measured and evacuated from the second reservoir. The fluid transfer valve is opened and the steps are repeated until the medical procedure is completed while the first reservoir remains in uninterrupted communication with the vacuum source during the medical procedure such that fluid is capable of continuing to be drawn into the first reservoir without interruption.

Abstract: A hybrid band intelligent backhaul radio (HB-IBR) is disclosed that is a combination of two radios operating in different bands. Embodiments include a dual radio configuration wherein a first radio operates in a non-line of sight (NLOS) radio link configuration and a second ancillary radio operates in a near line of sight or line of sight configuration (n)LOS. For example, the HB-IBR may have an Intelligent Backhaul Radio (IBR) operating in the non-line of sight mode of operation within the 5.8 GHz unlicensed band, and have an ancillary radio link operating in the FCC part 101 E band of operation at 60 GHz. A common medium access control (MAC) block may be utilized between the dual radios.

Abstract: Disclosed is a method for controlling cleaning at least a portion of a building facade (104a). A multi-dimensional map of a facade (104a) is cleaned from an elevator platform (200) of an elevator system is received. According to the map, an ordered sequence of instructions is determined. The instructions comprise robotic arm instructions and elevator platform instructions that are temporally intertwined to execute a cleaning pattern covering at least part of facade (104a). The robotic arm instructions are forwarded to control one or more robotic arms (206) and the elevator platform instructions are forwarded to control the elevation of the elevator platform (200). A corresponding device (221, 213) and non-transient memory (223), and a system having the device, are also disclosed.

Abstract: Disclosed herein, in part, is a pharmaceutical formulation comprising isotretinoin or a pharmaceutically acceptable salt thereof, and a mucoadhesive polymer. A method of treating a mucosal disease comprising administering a disclosed pharmaceutical formulation to a subject in need thereof is also provided herein.

Abstract: Multiple retail fuel stores are optimized using system having a computer in communication with a database. Remote computing devices are connected to the first computer by a communication system. Electronic signs receive an instruction over the communication system. The system creates a correlation matrix having fuel prices for the retail fuel stores, a reward discount, and competitor fuel prices, a profit for the fuel prices for each of the retail fuel stores, and a volume. It also creates an economic model that receives a number of correlation coefficients from the correlation matrix at the first computer. A multi-store optimization process configures the economic model to determine optimal fuel prices for retail fuel stores based on a total multi-store profit.

Abstract: Disclosed herein, in part, is a pharmaceutical formulation comprising isotretinoin or a pharmaceutically acceptable salt thereof, and a mucoadhesive polymer. A method of treating a mucosal disease comprising administering a disclosed pharmaceutical formulation to a subject in need thereof is also provided herein.

Abstract: A self-organizing backhaul radio (SOBR) and related arrangements are disclosed. A “primary” link between an first SOBR enabled radio and a second SOBR radio includes a secondary transmission link, referred to as a signature control channel (SCC), as a spread spectrum modulated signal embedded within and transmitted simultaneously with the primary link. The SCC transmissions from the first SOBR radio may be utilized by other SOBR enabled radios to determine an interference level to or from the first SOBR radio's primary link. The SCC transmission may be utilized to allow transmit beam forming between SOBR-enabled radios without damaging other friendly SOBR radios within the propagation distance of the transmitted signals based upon the detection of the SCC transmissions.