Patents Assigned to SLIL Biomedical Corporation
  • Novel quinones as disease therapies
    Publication number: 20050010060
    Abstract: Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
    Type: Application
    Filed: August 2, 2004
    Publication date: January 13, 2005
    Applicant: SLIL BIOMEDICAL CORPORATION
    Inventors: Andrei Blokhin, Benjamin Frydman, Laurence Marton, Karen Neder, Jerry Sun
  • Quinones as disease therapies
    Patent number: 6809176
    Abstract: Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: October 26, 2004
    Assignee: SLIL Biomedical, Corporation
    Inventors: Andrei V. Blokhin, Benjamin Frydman, Laurence J. Marton, Karen M. Neder, Jerry Shunneng Sun
  • Conjugates of porphyrin compounds with chemotherapeutic agents
    Publication number: 20040192665
    Abstract: Conjugates of porphyrins with chemotherapeutic agents are disclosed, as well as methods of making the conjugates and methods of treating patients with the conjugates. Porphyrin compounds, such as mesoporphyrin IX, can be covalently linked to chemotherapeutic compounds, such as doxorubicin. The resulting conjugates display decreased systemic toxicity, while preserving the antineoplastic effects of the chemotherapeutic agent. The conjugates are thus useful in treating cancer and other diseases marked by uncontrolled cell proliferation.
    Type: Application
    Filed: July 25, 2003
    Publication date: September 30, 2004
    Applicant: SLIL BIOMEDICAL CORPORATION
    Inventors: Benjamin Frydman, Aldonia L. Valasinas, John A. Kink, Laurence J. Marton
  • Conformationally restricted polyamine analogs as disease therapies
    Patent number: 6794545
    Abstract: Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of delivering these analogs specifically to tumor cells by covalently attaching polyamine analogs to, porphyrin compounds, along with novel polyamine-porphyrin covalent conjugates.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: September 21, 2004
    Assignee: SLIL Biomedical Corporation
    Inventors: Benjamin Frydman, Laurence J. Marton, Venodhar K. Reddy, Aldonia Valasinas, Andrei V. Blokhin, Hirak S. Basu
  • Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
    Publication number: 20040006049
    Abstract: Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
    Type: Application
    Filed: March 10, 2003
    Publication date: January 8, 2004
    Applicant: SLIL Biomedical Corporation
    Inventors: Benjamin Frydman, Laurence J. Marton
  • Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
    Patent number: 6649587
    Abstract: Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: November 18, 2003
    Assignee: SLIL Biomedical Corporation
    Inventors: Benjamin Frydman, Laurence J. Marton
  • Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
    Publication number: 20030195377
    Abstract: Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
    Type: Application
    Filed: December 6, 2002
    Publication date: October 16, 2003
    Applicant: SLIL Biomedical Corporation
    Inventors: Benjamin Frydman, Aldonia L. Valasinas, Andrei V. Blokhin, Aparajita Sarkar, Hirak S. Basu, Venodhar K. Reddy, Laurence J. Marton, Yu Wang
  • Oligoamine compounds and derivatives thereof for cancer therapy
    Publication number: 20030130356
    Abstract: Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.
    Type: Application
    Filed: October 16, 2002
    Publication date: July 10, 2003
    Applicant: SLIL Biomedical Corporation
    Inventors: Benjamin Frydman, Aldonia L. Valasinas, Andrei V. Blokhin, Hirak S. Basu, Laurence J. Marton
  • Novel quinones as disease therapies
    Publication number: 20020183512
    Abstract: Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
    Type: Application
    Filed: May 6, 2002
    Publication date: December 5, 2002
    Applicant: SLIL Biomedical Corporation
    Inventors: Andrei V. Blokhin, Benjamin Frydman, Laurence J. Marton, Karen M. Neder, Jerry Shunneng Sun
  • Quinones as disease therapies
    Patent number: 6482943
    Abstract: Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: November 19, 2002
    Assignee: SLIL Biomedical Corporation
    Inventors: Andrei V. Blokhin, Benjamin Frydman, Laurence J. Marton, Karen M. Neder, Jerry Shunneng Sun