Patents Assigned to Slingshot Biosciences, Inc.
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Patent number: 11927519Abstract: Synthetic human cell mimic hydrogel particles and their use in cytometric or coulter device applications are described. The synthetic human cell mimic hydrogel particles described herein are selectively tunable to have at least one optical, volumetric, or capacitance property that is substantially similar to a corresponding optical, volumetric, or capacitance property of the human cell mimic hydrogel particle's natural biological cell counterpart.Type: GrantFiled: April 26, 2023Date of Patent: March 12, 2024Assignee: Slingshot Biosciences, Inc.Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
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Publication number: 20240060038Abstract: The present disclosure provides feeder hydrogel particles that can function to support the growth, proliferation, and/or activation of a target cell in culture. The present disclosure also provides methods of culturing target cells with feeder hydrogel particles.Type: ApplicationFiled: November 1, 2023Publication date: February 22, 2024Applicant: Slingshot Biosciences, Inc.Inventors: Anh Tuan NGUYEN, Jeffrey KIM, Keunho AHN
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Publication number: 20240053248Abstract: A method includes calibrating a cytometric device for analysis of a target cell, by inserting, into the cytometric device, a hydrogel particle. The hydrogel particle has at least one of a background fluorescent property or a spectral property that is substantially similar to the at least one of a background fluorescent property or a spectral property of the target cell. The method also includes measuring at least one property of the hydrogel particle using the cytometric device.Type: ApplicationFiled: June 26, 2023Publication date: February 15, 2024Applicant: Slingshot Biosciences, Inc.Inventors: Jeffrey KIM, Anh Tuan NGUYEN, Brandon MILLER
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Patent number: 11761877Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.Type: GrantFiled: April 28, 2022Date of Patent: September 19, 2023Assignee: Slingshot Biosciences, Inc.Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
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Patent number: 11747261Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.Type: GrantFiled: July 20, 2020Date of Patent: September 5, 2023Assignee: Slingshot Biosciences, Inc.Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
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Publication number: 20230266223Abstract: Synthetic human cell mimic hydrogel particles and their use in cytometric or coulter device applications are described. The synthetic human cell mimic hydrogel particles described herein are selectively tunable to have at least one optical, volumetric, or capacitance property that is substantially similar to a corresponding optical, volumetric, or capacitance property of the human cell mimic hydrogel particle's natural biological cell counterpart.Type: ApplicationFiled: April 26, 2023Publication date: August 24, 2023Applicants: Slingshot Biosciences, Inc., Slingshot Biosciences, Inc.Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
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Patent number: 11726023Abstract: A method includes calibrating a cytometric device for analysis of a target cell, by inserting, into the cytometric device, a hydrogel particle. The hydrogel particle has at least one of a background fluorescent property or a spectral property that is substantially similar to the at least one of a background fluorescent property or a spectral property of the target cell. The method also includes measuring at least one property of the hydrogel particle using the cytometric device.Type: GrantFiled: April 25, 2022Date of Patent: August 15, 2023Assignee: Slingshot Biosciences, Inc.Inventors: Jeffrey Kim, Anh Tuan Nguyen, Brandon Miller
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Patent number: 11686661Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.Type: GrantFiled: November 18, 2022Date of Patent: June 27, 2023Assignee: Slingshot Biosciences, Inc.Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
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Publication number: 20230176042Abstract: Compositions comprising multiple hydrogel particles having substantially the same diameter, but with each subgrouping of particles from the multiple hydrogel particles having different associated values for one or more passive optical properties that can be deconvoluted using cytometric instrumentation. Each hydrogel particle from the multiple hydrogel particles can be functionalized with a different biochemical or chemical target from a set of targets. A method of preparing hydrogel particles includes forming droplets and polymerizing the droplets, with optional functionalization.Type: ApplicationFiled: February 3, 2023Publication date: June 8, 2023Applicant: Slingshot Biosciences, Inc.Inventors: Jeffrey KIM, Anh Tuan NGUYEN, Brandon MILLER
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Publication number: 20230152202Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.Type: ApplicationFiled: November 18, 2022Publication date: May 18, 2023Applicant: Slingshot Biosciences, Inc.Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
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Patent number: 11598768Abstract: Compositions comprising multiple hydrogel particles having substantially the same diameter, but with each subgrouping of particles from the multiple hydrogel particles having different associated values for one or more passive optical properties that can be deconvoluted using cytometric instrumentation. Each hydrogel particle from the multiple hydrogel particles can be functionalized with a different biochemical or chemical target from a set of targets. A method of preparing hydrogel particles includes forming droplets and polymerizing the droplets, with optional functionalization.Type: GrantFiled: May 4, 2021Date of Patent: March 7, 2023Assignee: Slingshot Biosciences, Inc.Inventors: Jeffrey Kim, Anh Tuan Nguyen, Brandon Miller
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Publication number: 20220364976Abstract: A method includes calibrating a cytometric device for analysis of a target cell, by inserting, into the cytometric device, a hydrogel particle. The hydrogel particle has at least one of a background fluorescent property or a spectral property that is substantially similar to the at least one of a background fluorescent property or a spectral property of the target cell. The method also includes measuring at least one property of the hydrogel particle using the cytometric device.Type: ApplicationFiled: April 25, 2022Publication date: November 17, 2022Applicant: Slingshot Biosciences, Inc.Inventors: Jeffrey KIM, Anh Tuan NGUYEN, Brandon MILLER
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Publication number: 20220260476Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.Type: ApplicationFiled: April 28, 2022Publication date: August 18, 2022Applicant: Slingshot Biosciences, Inc.Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
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Patent number: 11313782Abstract: A method includes calibrating a cytometric device for analysis of a target cell, by inserting, into the cytometric device, a hydrogel particle. The hydrogel particle has at least one of a background fluorescent property or a spectral property that is substantially similar to the at least one of a background fluorescent property or a spectral property of the target cell. The method also includes measuring at least one property of the hydrogel particle using the cytometric device.Type: GrantFiled: January 22, 2021Date of Patent: April 26, 2022Assignee: Slingshot Biosciences, Inc.Inventors: Jeffrey Kim, Anh Tuan Nguyen, Brandon Miller
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Patent number: 10942109Abstract: The present disclosure relates to compositions comprising a hydrogel particle with optical properties substantially similar to the optical properties of a target cell, and methods for their use.Type: GrantFiled: November 15, 2019Date of Patent: March 9, 2021Assignee: Slingshot Biosciences, Inc.Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
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Publication number: 20200400546Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.Type: ApplicationFiled: July 20, 2020Publication date: December 24, 2020Applicant: Slingshot Biosciences, Inc.Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
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Patent number: 10753846Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to the at least one optical property of a target cell. In this regard, the hydrogel particles provided herein in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.Type: GrantFiled: June 16, 2017Date of Patent: August 25, 2020Assignee: Slingshot Biosciences, Inc.Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
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Publication number: 20180275040Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to the at least one optical property of a target cell. In this regard, the hydrogel particles provided herein in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.Type: ApplicationFiled: June 16, 2017Publication date: September 27, 2018Applicant: Slingshot Biosciences, Inc.Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
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Patent number: 9714897Abstract: Hydrogel particles and their use in cytometic applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to the at least one optical property of a target cell. In this regard, the hydrogel particles provided herein in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.Type: GrantFiled: February 8, 2016Date of Patent: July 25, 2017Assignee: Slingshot Biosciences, Inc.Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen