Abstract: Melanoma can be treated in a mammalian subject by administering to the subject an immunologically-effective amount of a xenogeneic melanoma-associated differentiation antigen. For example, genetic immunization with a plasmid containing a sequence encoding human gp75 has been shown to be effective in treatment of dogs with melanoma.
Type:
Grant
Filed:
November 27, 2001
Date of Patent:
July 7, 2009
Assignee:
Sloan-Kettering Inststute for Cancer Research and The Animal Medical Center
Inventors:
Alan N. Houghton, Philip J. Bergman, Jedd D. Wolchok