Patents Assigned to Slovakofarma, A.S.
  • Method of omeprazole preparation
    Patent number: 6229021
    Abstract: The invention involves a method of preparation of omeprazole by a reaction of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-1H-benzimidazole with peroxyacetic acid in a two-phase water and chlorinated organic solvent medium, in alkaline pH, subsequent separation of water and organic phases after the reaction and isolation of omeprazole from organic phase.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: May 8, 2001
    Assignee: Slovakofarma, A.S.
    Inventors: Vendel {haeck over (S)}mahovský, Vladimir Oremus, Katarina Heleyová, Pavol Zlatoidský, Ond{haeck over (r)}ej Gattnar, Ivan Varga, Valdemar {haeck over (S)}talmach, Ladislav Je{haeck over (z)}ek