Abstract: A hermetically tight sealing device for motor-vehicles comprising a plurality of tubular sealing strips made of elastically deformable material functioning to ensure a hermetically tight seal with respect to the outer environment. Each strip extends along a rabbet edge of a respective door on the body of the motor-vehicle and is capable of being compressed and elastically deformed between the rabbet edge of the vehicle body and the edge of the respective door to provide a hermetically tight seal between the same. Each sealing strip is connected to a compressor to be inflated up to and maintained at a pre-established inner pressure during running of the motor vehicle, under control of a pressure switch.