Patents Assigned to SMALL MACHINES
  • Publication number: 20230236406
    Abstract: Disclosed are a method of acquiring an image using a light-emitting element array and an apparatus therefor. The method of acquiring an image using a light-emitting element array includes reconstructing a first image from some images among source images, detecting a partial region containing a detection target object from the first image, acquiring partial-region images corresponding to the partial region from each of the source images, and reconstructing a second image from the partial-region images using the FPMP.
    Type: Application
    Filed: March 3, 2021
    Publication date: July 27, 2023
    Applicant: SMALL MACHINES
    Inventors: Jun Kyu CHOI, Hyung Jin OH, Jin Kyu SEO, Oh Jun GWON, Kyung Hun Lee
  • Patent number: 11009691
    Abstract: Provided are a microscope apparatus and a method for correcting a position of a light source according to an exemplary embodiment of the present disclosure. The microscope apparatus for correcting the position of the light source according to the exemplary embodiment of the present disclosure includes: a light source unit which includes a light emitting element array including multiple light emitting elements and is configured to emit light to a subject; an optical unit which is disposed in parallel with the subject and configured to form an enlarged image of the subject to which the light is emitted; an image sensor which is configured to acquire the enlarged image of the subject by capturing the enlarged image formed by the optical unit; and a processor which is operably connected to the light source unit, the optical unit, and the image sensor and corrects a position of the light source unit based on the image acquired by the image sensor.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: May 18, 2021
    Assignees: Industry-Academic Cooperation Foundation, Yonsei University, Small Machines
    Inventors: Chul Min Joo, Seung Ri Song, Sunwoong Hur, Jun Kyu Choi, Chang Hyuk Yoo
  • Publication number: 20200355899
    Abstract: Provided are a microscope apparatus and a method for correcting a position of a light source according to an exemplary embodiment of the present disclosure. The microscope apparatus for correcting the position of the light source according to the exemplary embodiment of the present disclosure includes: a light source unit which includes a light emitting element array including multiple light emitting elements and is configured to emit light to a subject; an optical unit which is disposed in parallel with the subject and configured to form an enlarged image of the subject to which the light is emitted; an image sensor which is configured to acquire the enlarged image of the subject by capturing the enlarged image formed by the optical unit; and a processor which is operably connected to the light source unit, the optical unit, and the image sensor and corrects a position of the light source unit based on the image acquired by the image sensor.
    Type: Application
    Filed: May 5, 2020
    Publication date: November 12, 2020
    Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY, SMALL MACHINES
    Inventors: Chul Min JOO, Seung Ri SONG, Sunwoong HUR, Jun Kyu CHOI, Chang Hyuk YOO
  • Patent number: 10768401
    Abstract: There is provided a microscope apparatus and method for calibrating the position of a light source according to an embodiment of the present disclosure. A microscope apparatus according to an embodiment of the present disclosure includes: a light source unit configured to radiate light onto an subject and including a light emitting element array having a plurality of light emitting elements; an optical unit disposed in parallel with the subject and configured to form enlarged images of the subject receiving the radiated light; an image sensor configured to generate enlarged pictures of the subject based on the enlarged images formed through the optical unit; and a processor operably connected with the light source unit, the optical unit, and the image sensor, and calibrating a position of the light source unit based on a plurality of images generated by the image sensor.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: September 8, 2020
    Assignees: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY, SMALL MACHINES
    Inventors: Chul Min Joo, Seung Ri Song, Sun Woong Hur, Jun Kyu Choi
  • Publication number: 20200278348
    Abstract: The present invention provides a method of quantitatively analyzing an antigen, the method comprising: a step of mixing an assay sample comprising a target antigen, magnetic particles on which a first antibody subjected to an antigen-antibody reaction with the target antigen is immobilized, and beads on which a second antibody different from the first antibody is immobilized; a step of adding dropwise the mixed assay sample to a microchip for quantitatively analyzing an antigen; a step of introducing the microchip into a digital inline microscope-based detector comprising a magnetic force applicator and applying magnetism to the magnetic force applicator; and a step of detecting the beads using images acquired in the detector to count the number of the target antigens.
    Type: Application
    Filed: November 9, 2017
    Publication date: September 3, 2020
    Applicant: SMALL MACHINES
    Inventor: Jun Kyu CHOI
  • Publication number: 20200166504
    Abstract: The present invention provides a method of quantitatively analyzing a target substance, the method including a step of irradiating a biochip, which includes a plurality of target substances excluding a fluorescence-labeled material, with light; a step of acquiring a plurality of low-resolution images for a region including the plurality of target substances using an image sensor; a step of acquiring a high-resolution image based on the plurality of low-resolution images; and a step of counting the plurality of target substances in the high-resolution image; and a device for quantitatively analyzing a target substance using the method.
    Type: Application
    Filed: July 17, 2017
    Publication date: May 28, 2020
    Applicant: SMALL MACHINES
    Inventors: Jun Kyu CHOI, Gyeong Woo KANG
  • Publication number: 20200147611
    Abstract: Provided is a microchip for analyzing fluids, the microchip comprising a body that comprises an upper surface and a lower surface, wherein fluid flows to internal channels formed between the upper surface and the lower surface to detect a specific antigen in the fluid, wherein the internal channels comprise an input channel configured such that an assay sample is injected through a through hole penetrating the upper surface; a reaction channel configured to be in fluid communication with the input channel, to comprise magnetic particles on which a first antibody is immobilized, to comprise magnetic particles to which the first antibody, subjected to a first antigen-antibody reaction with the assay sample having flowed from the input channel, is immobilized, wherein the magnetic particles form immune complexes through the first antigen-antibody reaction, and to have a higher height than the lower surface forming the input channel; and a detection channel configured to be in fluid communication with the reactio
    Type: Application
    Filed: July 17, 2017
    Publication date: May 14, 2020
    Applicant: SMALL MACHINES
    Inventors: Jun Kyu CHOI, Gyeong Woo KANG, Na Hyun SONG
  • Patent number: 10180429
    Abstract: Provided are molecule immobilization patterns and a method for forming the same, thereby reducing noise that may occur while analyzing a signal, being stable even at room temperature, and improving orientation of immobilized materials.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: January 15, 2019
    Assignee: SMALL MACHINES CO., LTD.
    Inventors: Jun Kyu Choi, Jung Hoon Lee, Seung Soo Han, Choo Yeon Kim, Na Hyun Song