Abstract: A device for self-collection of a cervical sample includes an enclosure, a sample-collecting head, and a slider and a knob on the enclosure. The enclosure can be gripped by a user in one hand and inserted into the user's vaginal canal. The enclosure has an opening at one end, and a sample-collecting head can be advanced and retracted through the opening. The slider is on a side of the enclosure and is coupled to advance and retract the sample-collecting head, typically using a thumb. The knob is rotated by the user to rotate the sample-collecting head while the enclosure remains in the user's vaginal canal.