Abstract: Disclosed herein are systems and methods for the mass testing of a population for an infection. Pooled sampling may be used to reduce the number of tests needed for effective community surveillance. Individual members may be sorted into pools via a probability of infection to minimize the tests needed to identify positive individuals. The detection limits of testing assays may be used to help determine an appropriate pool size. Taxonomy tables characterizing the solution space of the total tests needed based on different variables may be generated and/or used to make testing decisions. Simulations of mass testing schemes may be used to facilitate testing decisions. Systems may be used to coordinate data and/or automate one or more steps of the testing process. Long-term community surveillance strategies may use prevalence testing, periodic mass testing via sample pooling, and/or periodic single sample testing to contain the spread of a contagion.