Abstract: A wire for cutting human soft tissue and a manufacturing method thereof are disclosed. The method includes at least: forming a first stranded wire using a plurality of element wires; forming a second stranded wire using the first stranded wires; washing the second stranded wire with acetone and alcohol; mounting the second stranded wire, subjected to the third step, in a vacuum arc deposition system equipped with a cathodic arc source; forming a vacuum level of 10?6 Torr or less in the vacuum system; cleaning the second stranded wire, subjected to the fourth step, in the vacuum system; and forming a hard coating layer of a compound containing titanium nitride (TiN) on the surface of the second stranded wire 3 at 400° C. in the vacuum system.