Abstract: Skin friendly pressure sensitive adhesives in the form of inherently tacky polyurethane-containing gells may be prepared by reacting an isocyanate prepolymer, which is itself the reaction product of poly-functional isocyanate and polyoxyalkylene diol monoalkyl ether, with a hydroxyl-containing ester of acrylic or methacrylic acid and optionally other hydroxyl containing compounds and then cross-linking the polymer so formed by means of irradiation. The proportion of acrylate chosen is such that it will react with at least 15 to 25% of the free isocyanate groups in the prepolymer and the remainder react with the other hydroxyl containing compound. The adhesives are capable of absorbing up to 95%, typically from 35 to 95% by weight of water when hydrated. The use of the adhesive in highly moisture vapor permeable dressings is also disclosed.