Patents Assigned to SmithKline Beckman Intercredit B.V.
  • Substituted 4-aminoquinoline derivatives as gastric secretion inhibitors
    Patent number: 5143920
    Abstract: Substituted 4-aminoquinazoline derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkoxy C.sub.1-6 alkyl,C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl C.sub.1-6 alkyl, phenyl C.sub.1-6 alkyl, the phenyl group being optionally substituted;R.sup.2 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, cyano, hydroxy, C.sub.1-6 alkanoyl or trifuromethyl;m is 1 to 3;R.sup.3 is hydrogen, C.sub.1-6 alkyl, phenyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, C.sub.1-6 alkanoyl, amino, C.sub.1-6 alkylamino, ci-C.sub.1-6 alkylamino, halogen, trifluoromethyl or cyano;n is 1 or 2; andR.sup.4 is hydrogen; or a salt thereof are useful as inhibitors of gastric acid secretion.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: September 1, 1992
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibitors
    Patent number: 5089498
    Abstract: Substituted 4-aminiquinazoline derivatives of the formula: ##STR1## in which R.sup.1 hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkoxyC.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkylC.sub.1-6 alkyl, phenylC.sub.1-6 alkyl, the phenyl group being optionally substituted;R.sup.2 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, cyano, hydroxy, carbamoyl, carboxy, C.sub.1-6 alkanoyl or trifluromethyl;m is 1 to 3;p is 0 to 4;R.sup.3 is COR.sup.4 ;R.sup.4 is hydroxy, C.sub.1-6 alkoxy, or NR.sup.5 R.sup.6 ;R.sup.5 and R.sup.6 are each hydrogen or C.sub.1-6 alkyl or together with the nitrogen atom to which they are attached form a heterocyclic ring; andR.sup.7 is hydrogen, C.sub.1-6 alkoxy or C.sub.1-6 alkyl;or a salt thereof.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: February 18, 1992
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibitors
    Patent number: 5089504
    Abstract: Substituted 4-aminoquinazoline derivatives of the formula: ##STR1## in which R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkoxyC.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkylC.sub.1-6 alkyl, phenylC.sub.1-6 alkyl, the phenyl group being optionally substituted;R.sup.2 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, cyano, hydroxy, carbamoyl, carboxy, C.sub.1-6 alkanoyl or trifluoromethyl;m is 1 to 3;p is 0 to 4;R.sup.3 is COR.sup.4 ;R.sup.4 is hydroxy, C.sub.1-6 alkoxy, or NR.sup.5 R.sup.6 ;R.sup.5 and R.sup.6 are each hydrogen or C.sub.1-6 alkyl or together with the nitrogen atom to which they are attached form a heterocyclic ring; andR.sup.7 is hydrogen, C.sub.1-6 alkoxy or C.sub.1-6 alkyl;or a salt thereof.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: February 18, 1992
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Dihydropyrrolo quinoline derivatives
    Patent number: 5051508
    Abstract: 1,4-Substituted 2,3-dihydropyrrolo[3,2-c]quinolines which are inhibitors of H.sup.+ K.sup.+ ATPase activity and useful as inhibitors of gastric acid secretion. A compound of the invention is 1-(2-methylphenyl)-4-amino-6-methyl-2,3-dihydropyrrolo[3,2-c]quinoline.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: September 24, 1991
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach
  • Substituted 4-aminoquinazoline derivatives and method of use
    Patent number: 5049567
    Abstract: Substituted 4-aminoquinazoline derivatives which are inhibitors of gastric acid secretion. A compound of the invention is ethyl 8-methoxy-4-(4-methyl-3-thinenylamino)quinoline-3-carboxylate.
    Type: Grant
    Filed: January 9, 1991
    Date of Patent: September 17, 1991
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Substituted 7-amino-thienopyridine derivatives as gastric acid secretion inhibitors
    Patent number: 4935431
    Abstract: Substituted 4-aminothienopyridine derivatives which are inhibitors of gastric acid secretion. A compound of the invention is 6-butyryl-7-(2-isopropylphenylamino)-thieno[3,2-b]pyridine.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: June 19, 1990
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach