Patents Assigned to SmithKline Beecham Corp.
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Publication number: 20030148465Abstract: Human HL TEX11 polypeptides and DNA (RNA) encoding such HL TEX11 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HL TEX11 for the treatment of atherosclerosis. inflammatory conditions. and infections. particularly viral infections such as AIDS. among others, among others. are also disclosed. Also disclosed are diagnostic assavs for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HL TEX11 and for detecting altered levels of the polypeptide in a host.Type: ApplicationFiled: February 19, 2003Publication date: August 7, 2003Applicant: SmithKline Beecham Corp.Inventors: Winnie Chan, Derk J. Bergsma, Catherine E. Ellis
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Publication number: 20030105138Abstract: A method of treatment using a compound of Formula I: 1Type: ApplicationFiled: December 19, 2002Publication date: June 5, 2003Applicant: Boehringer Mannheim Pharmaceuticals Corporation- SmithKline Beecham Corp. Limited Partnership No. 1Inventors: Mary Ann Lukas-Laskey, Robert Ruffolo, Neil Howard Shusterman, Gisbert Sponer, Klaus Strein
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Patent number: 6524555Abstract: A metered dose inhaler having part or all of its internal metallic surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising salmeterol, or a salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents and one or more excipients.Type: GrantFiled: May 3, 2000Date of Patent: February 25, 2003Assignee: SmithKline Beecham Corp.Inventors: Ian C. Ashurst, Ignatius Loy Britto, Craig Steven Herman, Li Li-Bovet, Michael Thomas Riebe
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Patent number: 6521667Abstract: The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.Type: GrantFiled: August 11, 1998Date of Patent: February 18, 2003Assignees: NPS Pharmaceuticals, Inc., SmithKline Beecham, PLC, SmithKline Beecham, Corp.Inventors: Eric G. Del Mar, Robert M. Barmore, Derek Sheehan, Bradford C. Van Wagenen, James F. Callahan, Richard M. Keenan, Nikesh R. Kotecha, Maria Amparo Lago, Linda Sue Southall, Mervyn Thompson
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Patent number: 6518404Abstract: A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinson's Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertension, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, ciclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.Type: GrantFiled: March 7, 2000Date of Patent: February 11, 2003Assignees: Human Genome Sciences, Inc., Smithkline Beecham Corp.Inventors: Yi Li, Craig A. Rosen, Chandrika Kumar
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Patent number: 6515027Abstract: This invention relates to substituted benzanilides which are ligands, agonists or antagonists, of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5, including, but not limited to, asthma and atopic disorders (for example, atopic dermatitis and allergies), rheumatoid arthritis, sarcoidosis and other fibrotic diseases, atherosclerosis, psoriasis, autoimmune diseases such as multiple sclerosis, and inflammatory bowel disease, all in mammals, by the use of substituted benzanilides which are CCR5 receptor antagonists. Furthermore, since CD8+ T cells have been implicated in COPD, CCR5 may play a role in their recruitment and therefore antagonists to CCR5 could provide potential therapeutic in the treatment of COPD. Also, since CCR5 is a co-receptor for the entry of HIV into cells, selective receptor ligands may be useful in the treatment of HIV infection.Type: GrantFiled: December 29, 1999Date of Patent: February 4, 2003Assignee: SmithKline Beecham Corp.Inventors: William E Bondinell, James A Chan
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Patent number: 6511653Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.Type: GrantFiled: February 18, 2000Date of Patent: January 28, 2003Assignee: SmithKline Beecham Corp.Inventors: Ignatius Loy Britto, Ian Car Ashurst, Craig Steven Herman, Li Li-Bovet, Michael Thomas Riebe
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Patent number: 6511652Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.Type: GrantFiled: February 18, 2000Date of Patent: January 28, 2003Assignee: SmithKline Beecham Corp.Inventors: Ian C. Ashurst, Ignatius Loy Britto, Craig Steven Herman, Li Li-Bovet, Michael Thomas Riebe
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Publication number: 20020156064Abstract: This invention relates to certain benzenesulfonamides and their use as PDE7 inhibitorsType: ApplicationFiled: February 28, 2002Publication date: October 24, 2002Applicant: SmithKline Beecham CorpInventors: Kelly M. Aubart, Siegfried B. Christensen, Jack D. Leber
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Patent number: 6391589Abstract: Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.Type: GrantFiled: January 7, 2000Date of Patent: May 21, 2002Assignees: Human Genome Sciences, Inc., SmithKline Beecham, Corp.Inventors: Henrik S. Olsen, Haodong Li, Mark D. Adams, Solange H. L. Gentz, Ralph Alderson, Yuling Li, David Parmelee, John R. White, Edward R. Appelbaum
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Patent number: 6350598Abstract: The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.Type: GrantFiled: April 13, 1999Date of Patent: February 26, 2002Assignee: SmithKline Beecham Corp.Inventors: Nicola Gail Wallis, Joanna Lynn Fueyo, Michael Arthur Lonetto
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Patent number: 6350857Abstract: The invention provides ffh polypeptides and DNA (RNA) encoding ffh polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ffh polypeptides to screen for antibacterial compounds.Type: GrantFiled: August 30, 1999Date of Patent: February 26, 2002Assignee: SmithKline Beecham Corp.Inventor: Michael Terence Black
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Patent number: 6350600Abstract: The invention provides trmA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recominant techniques from strepococcus pneumoniae. Also provided are methods for utilizing polypepides to screen for antibacterial compounds.Type: GrantFiled: July 28, 2000Date of Patent: February 26, 2002Assignee: SmithKline Beecham Corp.Inventors: Sanjoy Biswas, James Raymond Brown, Chi Young So, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B Mathie, Richard Lloyd Warren, Magdalena Zalacain
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Patent number: 6346393Abstract: The invention provides RncS polypeptides and DNA (RNA) encoding RncS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing RncS polypeptides to screen for antibacterial compounds.Type: GrantFiled: November 6, 1997Date of Patent: February 12, 2002Assignee: SmithKline Beecham Corp.Inventors: Jason Craig Fedon, Michael Arthur Lonetto, Leslie Marie Palmer, Martin Rosenberg, Richard Lloyd Warren
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Patent number: 6346395Abstract: The invention provides FabG polypeptides and polynucleotides encoding FabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabG polypeptides to screen for antibacterial compounds.Type: GrantFiled: January 27, 1999Date of Patent: February 12, 2002Assignee: SmithKline Beecham Corp.Inventors: Alison Francis Chalker, Christine Debouck, David John Holmes, Karen Anne Ingraham, Deborah Dee Jaworski, Anna Lisa Kosmatka, Damien McDevitt, Jeffrey Mooney, Stewart C Pearson, Chi Yong So, Nicola Gail Wallis, Min Wang, Richard Lloyd Warren, Yi Yi Zhong
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Patent number: 6331410Abstract: The invention provides pyrR homolog polypeptides and DNA (RNA) encoding pyrR homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pyrR homolog polypeptides to screen for antibacterial compounds.Type: GrantFiled: August 29, 1997Date of Patent: December 18, 2001Assignee: SmithKline Beecham Corp.Inventors: Martin Karl Russel Burnham, Michael Arthur Lonetto, Patrick Vernon Warren
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Patent number: 6329168Abstract: The invention provides ileS polypeptides and DNA (RNA) encoding ileS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ileS polypeptides to screen for antibacterial compounds.Type: GrantFiled: October 17, 1997Date of Patent: December 11, 2001Assignee: SmithKline Beecham Corp.Inventors: James R. Brown, Deborah D. Jaworski, Elizabeth J. Lawlor, Min Wang
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Patent number: 6326170Abstract: The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.Type: GrantFiled: May 10, 1999Date of Patent: December 4, 2001Assignee: SmithKline Beecham Corp.Inventors: Martin Karl Russel Burnham, Michael Arthur Lonetto, Patrick Vernon Warren
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Patent number: 6326167Abstract: The invention provides tktA polypeptides and polynucleotides encoding tktA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tktA polypeptides and polynucleotides to screen for antibacterial compounds and for the detection of Streptococcus pneumoniae.Type: GrantFiled: April 23, 1999Date of Patent: December 4, 2001Assignee: SmithKline Beecham Corp.Inventors: Alison F Chalker, Sauli J Haataja, David W Holden, David J Holmes, Karen A Ingraham, Gee W Lau, Andrea Marra, Michael A Lonetto, Damien McDevitt, Jennifer Ray, Jun Yu
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Patent number: 6326172Abstract: The invention provides ytgP polypeptides and polynucleotides encoding ytgP polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ytgP polypeptides to screen for antibacterial compounds.Type: GrantFiled: November 4, 1999Date of Patent: December 4, 2001Assignee: SmithKline Beecham Corp.Inventors: Sanjoy Biswas, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Patrick Vernon Warren, Stephanie Van Horn, Magdalena Zalacain