Abstract: NK3 receptor antagonists of formula (I):
in which:
Ar is an optionally substituted phenyl group, or a naphthyl or C5-7 cycloalkdienyl group, or an optionally substituted single or fused ring heterocyclic group, having aromatic character, containing from 5 to 12 ring atoms and comprising up to four hetero-atoms in the or each ring selected from S, O, N;
R is linear or branched C1-8 alkyl, C3-7 cycloalkyl, C4-7 cycloalkylalkyl, an optionally substituted phenyl group or a phenyl C1-6 alkyl group, an optionally substituted five-membered heteroaromatic ring comprising up to four heteroatoms selected from O and N, hydroxy C1-6 alkyl, amino C1-6 alkyl, C1-6 alkylaminoalkyl, di C1-6 alkylaminoalkyl, C1-6 acylaminoalkyl, C1-6 alkoxyalkyl, C1-6 alkylcarbonyl, carboxy, C1-6 alkoxyxcarbonyl, C1-6 alkoxycarbonyl C1-6 alkyl, aminocarbonyl, C1-6 alkylaminocarbonyl, di C1-6 alkylaminocarbonyl, halogeno C1-6 alkyl; or is a group —(CH2)p— when cyclized onto Ar, where p is 2 or 3;
R1 and R2, whi
Type:
Grant
Filed:
May 25, 1995
Date of Patent:
August 19, 2003
Assignee:
SmithKline Beecham Farmaceutici S.p.A
Inventors:
Carlo Farina, Giuseppe Arnaldo Maria Giardina, Mario Grugni, Luca Francesco Raveglia
Abstract: Compounds of formula (I), are selective delta opioid agonsist and antagonists, and are useful as analgesics and in treating general neurologic disorders.
Abstract: NK.sub.3 receptor antagonists of formula (I): ##STR1## are useful in treating inter alia pulmonary disorders, CNS disorders and neurodegenerative disorders.
Type:
Grant
Filed:
May 25, 1995
Date of Patent:
September 22, 1998
Assignee:
SmithKline Beecham Farmaceutici S.p.A.
Inventors:
Carlo Farina, Giuseppe Arnaldo Maria Giardina, Mario Grugni, Luca Francesco Raveglia
Abstract: Pharmaceutical compositions comprising a calcitonin and a polyglycolysed glyceride and a method of enhancing the transdermal or transmucosal absorption of calcitonin in a mammal are disclosed.
Type:
Grant
Filed:
June 19, 1995
Date of Patent:
February 17, 1998
Assignee:
SmithKline Beecham Farmaceutici S.p.A.
Inventors:
Laura Chiodini, Teodoro Fonio, Gianfranco Rancati