Patents Assigned to Smithkline Beecham Intercredit B.V.
  • Compounds substituted quinoline derivatives
    Patent number: 5432182
    Abstract: Substituted 4-aminoquinazoline derivatives which are inhibitors of gastric acid secretion. A compound of the invention are the salts of strong acids of 3-butyryl-4-(2-methylphenylamino)-8-(hydroxymethyl)quinoline.
    Type: Grant
    Filed: January 29, 1992
    Date of Patent: July 11, 1995
    Assignee: SmithKline Beecham Intercredit B.V.
    Inventors: Robert J. Ife, Colin A. Leach
  • [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders
    Patent number: 5409943
    Abstract: The present invention relates to N-pyridylamidine and N-pyridylguanidine derivatives of general formula (I) in which: Ar.sup.1 is an optionally substituted phenyl ring; Ar.sup.2 is an optionally substituted phenyl ring; R.sup.1 is hydrogen or C.sub.1-4 alkyl; R.sup.2 is hydrogen or C.sub.1-4 alkyl; R.sup.3 is hydrogen or C.sub.1-4 alkyl; R.sup.4 is hydrogen, halogen, C.sub.1-6 alkyl or C.sub.1-6 alkoxy; X is CH.sub.2 or NR.sup.5, and R.sup.5 is hydrogen or C.sub.1-4 alkyl, and the salts thereof, and their use in therapy as gastric acid secretion inhibitors.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: April 25, 1995
    Assignee: SmithKline Beecham Intercredit B.V.
    Inventors: Robert J. Ife, Colin A. Leach, Dashyant Dhanak
  • Thienopyrimidines
    Patent number: 5280026
    Abstract: Thienopyrimidine compounds are disclosed as inhibitors of the H.sup.+ K.sup.+ ATPase enzyme useful in the treatment of gastric acid secretion. A compound of the invention is 2-(2-methylphenylamino)-4-(N-methylphenylamino)thieno[3,2-d]pyrimidine.
    Type: Grant
    Filed: November 24, 1992
    Date of Patent: January 18, 1994
    Assignee: SmithKline Beecham Intercredit B.V.
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach
  • Substituted 4-amino-isoquinoline compounds, pharmaceutical composition and method of use
    Patent number: 5200417
    Abstract: Isoquinoline compounds, compositions containing them and their use in the inhibition of gastric acid secretion in mammals. A compound of the invention is 1-[(2-Methoxyphenylmethyl)amino]isoquinoline hydrochloride.
    Type: Grant
    Filed: April 4, 1990
    Date of Patent: April 6, 1993
    Assignee: Smithkline Beecham Intercredit B.V.
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach
  • 3-carbonyl-4-amino-8-substituted quinoline compounds useful in inhibiting gastric acid secretions.
    Patent number: 5082841
    Abstract: Aminoquinoline derivatives are described as inhibitors of the H.sup.+ K.sup.+ ATPase enzyme useful in the treatment of gastric acidity. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-(3-dimethylaminopropoxy)quinoline.
    Type: Grant
    Filed: August 7, 1990
    Date of Patent: January 21, 1992
    Assignee: SmithKline Beecham Intercredit B.V.
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach
  • Substituted quinazoline derivatives for use in gastrointestinal diseases
    Patent number: 5064833
    Abstract: 2,4-diaminoquinazoline compounds are inhibitors of the H.sup.+ K.sup.+ ATPase enzyme and useful for the treatment of diseases of the stomach based on excessive gastric acid secretion. A compound of the invention is 2-[2-methyl-4-fluorophenyl)amino]-4-(N-methylphenylamino)quinazoline.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: November 12, 1991
    Assignee: Smithkline Beecham Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach, David J. Keeling