Patents Assigned to SmithKline Beecham Laboratoires Pharmaceutiques
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Publication number: 20040254229Abstract: A method for reducing or preventing apoptosis of differentiated cells selected from the list consisting of cardiac myocytes, pancreatic beta cells, endothelial cells and neuronal cells in the human or non-human mammal, which method comprises administration, including acute administration, of an effective, non-toxic amount of a glucose uptake enhancer to a human or non-human mammal in need thereof.Type: ApplicationFiled: March 10, 2004Publication date: December 16, 2004Applicant: SmithKline Beecham p.l.c. and SmithKline Beecham Laboratoires PharmaceutiquesInventors: Antoine Michel Alain Bril, Robin Edwin Buckingham, Nassirah Khandoudi
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Publication number: 20040110800Abstract: A method for reducing post-ischaemic injury of the heart and/or improving the functional recovery of the heart following myocardial ischaemia which method comprises administration of an effective, non-toxic amount of a glucose uptake enhancer to a human or non-human mammal in need thereof.Type: ApplicationFiled: December 2, 2003Publication date: June 10, 2004Applicant: SmithKline Beecham p.l.c. & SmithKline Beecham Laboratoires PharmaceutiquesInventors: Antoine Michel Alain Bril, Robin Edwin Buckingham, Nassirah Khandoudi
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Patent number: 6699889Abstract: A method for reducing post-ischaemic injury of the heart and/or improving the functional recovery of the heart following myocardial ischaemia which method comprises administration of an effective, non-toxic amount of a glucose uptake enhancer to a human or non-human mammal in need thereof.Type: GrantFiled: June 12, 2003Date of Patent: March 2, 2004Assignees: SmithKline Beecham p.l.c., SmithKline Beecham Laboratoires PharmaceutiquesInventors: Antoine Michel Alain Bril, Robin Edwin Buckingham, Nassirah Khandoudi
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Publication number: 20030216455Abstract: A method for reducing post-ischaemic injury of the heart and/or improving the functional recovery of the heart following myocardial ischaemia which method comprises administration of an effective, non-toxic amount of a glucose uptake enhancer to a human or non-human mammal in need thereof.Type: ApplicationFiled: June 12, 2003Publication date: November 20, 2003Applicant: SmithKline Beecham plc & SmithKline Beecham Laboratoires PharmaceutiquesInventors: Antoine Michel Alain Bril, Robin Edwin Buckingham, Nassirah Khandoudi
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Publication number: 20030124187Abstract: Novel coamoxiclav formulations are described, having reduced weight compared to existing formulations, as well as formulations comprising amoxycillin and potassium clavulanate in a ratio of 8:1 and formulations prepared from granulates of amoxycillin and granulates of amoxycillin and clavulanate.Type: ApplicationFiled: November 22, 2002Publication date: July 3, 2003Applicants: SmithKline Beecham Laboratoires Pharmaceutiques,, SmithKline Beecham s.a., SmithKline Beecham CorporationInventors: Jacky Andre Gustave Mention, Jose Luis Sanroma Bordallo, Kevin Huntley Storm
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Patent number: 6570037Abstract: A compound of formula (I): or a salt thereof, or a solvate thereof, wherein Ar represents substituted or unsubstituted aryl, wherein the optional substituents are selected from alkyl, hydroxy or alkoxy or, if attached to adjacent carbon atoms any two substituents together with the carbon atoms to which they are attached may form a fused heterocyclic ring of five to six atoms wherein one, two or three of the said atoms are oxygen or nitrogen; A represents a C1-4 n-alkylene group wherein each carbon is optionally substituted by 1 or 2 C1-6 alkyl groups; R1 represents hydrogen, alkyl, alkenyl or cycloalkyl; one or two of of the group of R2, R3 and R4 represents nitro the remaining members of the group of R2, R3 and R4 represent hydrogen; X represents a —CO—NH— moiety; and Z represents C2-4 n-alkylene group wherein each carbon is optionally substituted 1 or 2 C1-6 alkyl groups; a process for preparing such compounds, pharmaceutical compositions comprising such compounds and the use of such compoType: GrantFiled: January 30, 2002Date of Patent: May 27, 2003Assignee: SmithKline Beecham Laboratoires PharmaceutiquesInventors: Guy Marguerite Marie Gerard Nadler, Michel Jean Roger Martin
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Publication number: 20020107243Abstract: A compound of formula (I): or a salt thereof, or a solvate thereof, wherein Ar represents substituted or unsubstituted aryl, wherein the optional substituents are selected from alkyl, hydroxy or alkoxy or, if attached to adjacent carbon atoms any two substituents together with the carbon atoms to which they are attached may form a fused heterocyclic ring of five to six atoms wherein one, two or three of the said atoms are oxygen or nitrogen; A represents a C1-4 n-alkylene group wherein each carbon is optionally substituted by 1 or 2 C1-6 alkyl groups; R1 represents hydrogen, alkyl, alkenyl or cycloalkyl; one or two of of the group of R2, R3 and R4 represents nitro the remaining members of the group of R2, R3 and R4 represent hydrogen; X represents a —CO—NH— moiety; and Z represents C2-4 n-alkylene group wherein each carbon is optionally substituted 1 or 2 C1-6 alkyl groups; a process for preparing such compounds, pharmaceutical compositions comprising such compounds and the use of such compoType: ApplicationFiled: January 30, 2002Publication date: August 8, 2002Applicant: SmithKline Beecham Laboratoires PharmaceutiquesInventors: Guy Marguerite Marie Gerard Nadler, Michel Jean Roger Martin
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Publication number: 20020099080Abstract: A compound of formula (I): 1Type: ApplicationFiled: October 11, 2001Publication date: July 25, 2002Applicant: SmithKline Beecham Laboratoires PharmaceutiquesInventors: Stefania Gagliardi, Guy Marguerite Marie Gerard Nadler, Pietro A. T. Novella
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Patent number: 6368823Abstract: hKv4.3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hKv4.3 polypeptides and polynucleotides in the design of protocols for the treatment of cardiac arrhythmias and Alzheimer's disease, among others, and diagnostic assays for such conditions.Type: GrantFiled: February 2, 1999Date of Patent: April 9, 2002Assignee: SmithKline Beecham Laboratoires PharmaceutiquesInventors: Antoine Michel Alain Bril, Thierry Paul Gerard Calmels, Jean-Francois Simon Pierre Faivre, Jean-Luc Javre, Sabine Rouanet
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Patent number: 6274172Abstract: Granulates comprising an effervescent couple of anhydrous powdered monosodium citrate and powdered sodium bicarbonate and prepared using a roller compactor are formulated into pharmaceutical compositions.Type: GrantFiled: September 3, 1998Date of Patent: August 14, 2001Assignee: SmithKline Beecham Laboratoires PharmaceutiquesInventor: Jacky Andre Gustave Mention
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Patent number: 6197069Abstract: Putative Adrenomedullin Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Putative Adrenomedullin Receptor polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension, urinary retention, osteoporosis; angina pectoris; myocardial infarction, ulcers; asthma; allergies; benign prostatic hypertrophy; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome; and pre-eclampsia, among others and diagnostic assays for such conditions.Type: GrantFiled: September 3, 1998Date of Patent: March 6, 2001Assignees: SmithKline Beecham Corporation, SmithKline Beecham Laboratoires PharmaceutiquesInventors: George Henry Poste, Michel Louis Souchet, Philippe Laurent Robert, Stephane Clement Krief, Bernard Emile Joseph Gout, Eve Mahe
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Patent number: 5712284Abstract: A compound of formula (I) or a salt thereof, or a solvate thereof: ##STR1## wherein B represents a C.sub.1-4 n-alkylene group wherein each carbon is optionally substituted by a C.sub.1-6 alkyl group; Z represents a bond, CH.sub.2, (CH.sub.2).sub.2 or X--CH.sub.2 --CH.sub.2 wherein X represents O or S; D represents CO, SO.sub.2, NH--CO or NH--SO.sub.2 ; T represents a bond and U represents CH.sub.2 or T represents CH.sub.Type: GrantFiled: February 14, 1996Date of Patent: January 27, 1998Assignee: SmithKline Beecham Laboratoires PharmaceutiquesInventors: Guy Marguerite Marie Gerard Nadler, Michel Louis Souchet