Patents Assigned to SmithKline Beecham S.p.A.
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Patent number: 6780875Abstract: A compound, or a solvate or a salt thereof, of formula (I): wherein, Ar is an optionally substituted aryl or a C5-7 cycloalkdienyl group, or an optionally substituted C5-7 cycloalkyl group, or an optionally substituted single or fused ring aromatic heterocyclic group; R is hydrogen, linear or branched C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkylalkyl; R1 represents hydrogen or up to three optional substituents selected from the list consisting of: C1-6 alkyl, C1-6 alkenyl, aryl, C1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamido, sulphonamido, C1-6 alkoxycarbonyl, trifluoromethyl, acyloxy, amino or mono- and di-C1-6 alkylamino, R2 represents a moiety —(CH2)n—NYY2 wherein n is an integer in the range of from 1 to 9, Y1 and Y2 are independently selected from C1-6-alkyl; C1-6 alkyl substituted with hydroxy, alkoxy, C1-6 alkylamino or bis (C1-6 alkyl) amino; C3-6 cycloalkyl; C4-6 azacycloalkyl; C1-6-alkenyl; aryl or aryl-C1-6-alkyl or Y1 and Y2 together with the nitType: GrantFiled: February 5, 2003Date of Patent: August 24, 2004Assignees: SmithKline Beecham S.p.A., SmithKline Beecham Laboratories PharmaceutiquesInventors: Carlo Farina, Giuseppe Giardina, Mario Grugni, Marcel Morvan, Guy Marguerite Marie GĂ©rard Nadler, Luca Francesco Raveglia
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Patent number: 6743804Abstract: The present invention relates to a novel use, in particular a novel pharmaceutical use for a series of quinoline derivatives.Type: GrantFiled: May 7, 2002Date of Patent: June 1, 2004Assignee: SmithKline Beecham S p.A.Inventors: Giuseppe Arnaldo Maria Giardina, Carlo Farina, Mario Grugni, Luca Francesco Raveglia
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Patent number: 6696457Abstract: Heterocycle condensed morphinoid derivatives of formula (I) have therapeutic utility as analgesics, in collagen disease, as anti-allergic and anti-inflammatory agents, brain cell protectants, in gastritis, diarrhoea, cardiovascular and respiratory diseases, cough, mental illness, epilepsy, for the preservation of organs during transplant operations, and for the treatment of those pathological conditions which customarily can be treated with agonists of the delta opioid receptor.Type: GrantFiled: April 2, 2002Date of Patent: February 24, 2004Assignees: SmithKline Beecham p.l.c., SmithKline Beecham S.p.A.Inventors: Stephen Edward Clarke, Giulio Dondio, Luca Francesco Raveglia, Silvano Ronzoni
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Publication number: 20030212101Abstract: A compound, or a solvate or a salt thereof, of formula (I): 1Type: ApplicationFiled: February 5, 2003Publication date: November 13, 2003Applicant: SmithKline Beecham S.p.A.Inventors: Carlo Farina, Giuseppe Giardina, Mario Grugni, Marcel Morvan, Guy Marguerite Marie Gerard Nadler, Luca Francesco Raveglia
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Publication number: 20030195204Abstract: The present invention relates to a novel use, in particular a novel pharmaceutical use for a series of quinoline derivatives.Type: ApplicationFiled: May 7, 2002Publication date: October 16, 2003Applicant: SmithKline Beecham S.p.A.Inventors: Giuseppe Arnaldo Maria Giardina, Carlo Farina, Mario Grugni, Luca Francesco Raveglia
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Patent number: 6613770Abstract: A compound, or a solvate or a salt thereof, of formula (I): wherein R is linear or branched alkyl; R1 represents hydrogen or up to four optional substituents selected from the list consisting of: C1-6 alkyl, C1-6 alkenyl, aryl, C1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamido, sulphonamido, C1-6 alkoxycarbonyl, trifluoromethyl, acyloxy, phthalimido, amino or mono- and di-C1-6 alkylamino; R2 represents a moiety —(CH2)n—NY1Y2 wherein n is an integer in the range of from 1 to 9, Y1 and Y2 are independently selected from hydrogen; C1-6-alkyl; C1-6 alkyl substituted with hydroxy, C1-6 alkylamino or bis (C1-6 alkyl) amino; C1-6-alkenyl; aryl or aryl-C1-6-alkyl or Y1 and Y2 together with the nitrogen atom to which they are attached represent an optionally substituted N-linked single or fused ring heterocyclic group; R3 is branched or linear C1-6 alkyl, C3-7 cycloalkyl, C4-7 cycloalkylalkyl, optionally substituted aryl, or an optionally substituted single or fused rinType: GrantFiled: September 28, 2001Date of Patent: September 2, 2003Assignees: SmithKline Beecham S.p.A., SmithKline Beecham Laboratoires PhamaceutiquesInventors: Carlo Farina, Giuseppe Giardina, Mario Grugni, Guy Marguerite Marie Gerard Nadler, Luca Francesco Raveglia
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Publication number: 20020156097Abstract: A compound of formula (I) or a solvate thereof, characterized in that salt comprises a compound of formula (I) in anionic form and a salting cation; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.Type: ApplicationFiled: June 12, 2002Publication date: October 24, 2002Applicant: SmithKline Beecham S.p.A.Inventors: Giuseppe Arnaldo Maria-Giardina, Carlo Farina, Mario Grugni, Luca Francesco Raveglia
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Patent number: 6432977Abstract: A compound of formula (I) or a solvate thereof, characterized in that salt comprises a compound of formula (I) in anionic form and a salting cation; a process from preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.Type: GrantFiled: November 6, 2001Date of Patent: August 13, 2002Assignee: SmithKline Beecham S.p.A.Inventors: Giuseppe Arnaldo Maria Giardina, Carlo Farina, M. Grugni, Luca Francesco Raveglia
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Publication number: 20020077335Abstract: A compound of formula (I) or a solvate thereof, characterized in that salt comprises a compound of formula (I) in anionic form and a salting cation; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.Type: ApplicationFiled: November 6, 2001Publication date: June 20, 2002Applicant: SmithKline Beecham S.p.A.Inventors: Giuseppe Arnaldo Giardina, Carlo Farina, M. Grugni, Luca Francesco Raveglia
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Publication number: 20020068827Abstract: A compound of formula (I): 1Type: ApplicationFiled: November 26, 2001Publication date: June 6, 2002Applicant: SmithKline Beecham S.p.A.Inventors: Giuseppe Arnaldo Maria Giardina, Mario Grugni, Luca Francesco Raveglia, Carlo Farina
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Patent number: 6365594Abstract: Heterocycle-condensed morphinoid derivatives of formula (I), or solvates or salts thereof, are potent and selective delta opioid agonists and antagonists and are useful as i.a. analgesics. Pharmaceutical compositions containing such compounds, the use of such compounds as therapeutic agents, a method of treatment comprising the administration of such compounds, and a process for the preparation of such compounds are also described.Type: GrantFiled: February 22, 1999Date of Patent: April 2, 2002Assignee: SmithKline Beecham S.p.A.Inventors: Giulio Dondio, Silvano Ronzoni, Pier Andrea Gatti, Davide Graziani
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Patent number: 6355654Abstract: A compound of formula (I) or a solvate thereof, characterized in that salt comprises a compound of formula (I) in anionic form and a salting cation; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.Type: GrantFiled: May 21, 1998Date of Patent: March 12, 2002Assignee: SmithKline Beecham S.p.A.Inventors: Giuseppe Arnaldo Maria Giardina, Carlo Farina, Mario Grugni, Luca Francesco Raveglia
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Patent number: 6277862Abstract: A compound, or a solvate or a salt thereof, of formula (I), wherein, Ar is an optionally substituted aryl or a C5-7 cycloalkdienyl group, or an optionally substituted single or fused ring aromatic heterocyclic group; R, R1, R2 and R3 are as defined in the description; a process for the preparation of such a compound, a pharmaceutical composition containing such a compound or composition in medicine.Type: GrantFiled: May 22, 1998Date of Patent: August 21, 2001Assignee: SmithKline Beecham S.p.A.Inventors: Giuseppe Arnaldo Maria Giardina, Mario Grugni, Luca Francesco Raveglia, Carlo Farina
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Patent number: 5968949Abstract: According to the present invention, there is provided a compound, or a solvate or salt thereof of formula (I): ##STR1## Substituted hydroisoquinoline derivatives are potent and selective delta opioid agonists and antagonists and are of potential therapeutic utility as inter alia analgesics.Type: GrantFiled: May 29, 1998Date of Patent: October 19, 1999Assignee: SmithKline Beecham S.p.A.Inventors: Giulio Dondio, Silvano Ronzoni
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Patent number: 5731322Abstract: Tricyclic derivatives of octahydroisoquinoline of formula (I), wherein n is zero or 1 and if n is zero, one of X or Y is NH, oxygen or sulphur, and the other is NH, CH or a R.sub.4 - or R.sub.5 -substituted carbon atom; if n is 1, then X and Y are both nitrogen, or one of them is nitrogen and the other is CH or an R.sub.4 - or R.sub.5 -substituted carbon atom, have selective receptor agonist or antagonist activity, and are of potential therapeutic utility as analgesics or immunomodulating and/or cardiovascular agents.Type: GrantFiled: April 18, 1996Date of Patent: March 24, 1998Assignee: SmithKline Beecham S.p.A.Inventors: Giulio Dondio, Silvano Ronzoni