Abstract: Peptide mimics, having a constrained peptide backbone conformation, are HIV protease inhibitors. A compound of this invention is, for example, 3-Benzyl-5(alaninyl-1-aminoethyl)-2,3,6,7-tetrahydro-N-azepinyl-2-propiony l-valinyl-valinyl methyl ester.
Type:
Grant
Filed:
July 26, 1993
Date of Patent:
August 1, 1995
Assignee:
SmithKline Beechman Corp.
Inventors:
James F. Callahan, William F. Huffman, Michael L. Moore, Kenneth A. Newlander