Abstract: Orthodontic appliances formed from a material that includes an interpenetrating polymer network or semi-interpenetrating polymer network material to prevent or reduce stress relaxation of the material during use by a patient. Methods for forming orthodontic appliances from a material that includes from an interpenetrating polymer network or semi-interpenetrating polymer network material to prevent or reduce stress relaxation of the material during use by a patient.

Abstract: A system and method for generating a 3D-printed medical appliance treatment plan and providing a set of 3D-printed medical appliances in accordance therewith, the method comprising: generating a dynamic 3D-printed medical appliance treatment plan generation model; obtaining a patient record; receiving 3D scanning data of the patient; generating a 3D-printed medical appliance treatment plan by applying the patient record and the 3D scanning data to the dynamic 3D-printed medical appliance treatment plan generation model; providing the 3D-printed medical appliance treatment plan to a medical practitioner; providing a manufacturing request to a manufacturer system for manufacturing a set of 3D-printed medical appliances; providing the set of 3D-printed medical appliances to the patient; receiving feedback from the medical practitioner regarding the 3D-printed medical appliance treatment plan; modifying the dynamic 3D-printed medical appliance treatment plan generation model based on the feedback.

Abstract: An orthodontic appliance is constructed from shells shaped to receive teeth. The shells can be constructed from one or more polymer materials and stacked and also varyingly affixed to one another, which can include affixing only about the edge of each shell. The orthodontic appliance can be one of a series of similar appliances for incremental orthodontic modification of teeth.

Abstract: An orthodontic appliance is constructed from shells shaped to receive teeth. The shells can be constructed from one or more polymer materials and affixed to one another about the edge of each shell, defining a narrow elongate chamber therebetween. The chamber serves to allow for the first shell contacting the teeth to flex and fit a wide range of teeth without sacrificing the overall flexural modulus of the appliance. Methods of making the appliance are also described.

Abstract: Orthodontic appliances formed from a material that includes an interpenetrating polymer network or semi-interpenetrating polymer network material to prevent or reduce stress relaxation of the material during use by a patient. Methods for forming orthodontic appliances from a material that includes from an interpenetrating polymer network or semi-interpenetrating polymer network material to prevent or reduce stress relaxation of the material during use by a patient.

Abstract: In certain aspects, devices and methods for an oral appliance holder that can detect analyte information originating from oral appliances stored in the appliance holder. The analyte information can be derived from found in volatilized compounds detected within the appliance holder. The appliance holder can directly or indirectly communicate with a server that is configured to process the analyte information. The analyte information can be processed to develop a wellness profile.

Abstract: A system and method for generating a 3D-printed medical appliance treatment plan and providing a set of 3D-printed medical appliances in accordance therewith, the method comprising: generating a dynamic 3D-printed medical appliance treatment plan generation model; obtaining a patient record; receiving 3D scanning data of the patient; generating a 3D-printed medical appliance treatment plan by applying the patient record and the 3D scanning data to the dynamic 3D-printed medical appliance treatment plan generation model; providing the 3D-printed medical appliance treatment plan to a medical practitioner; providing a manufacturing request to a manufacturer system for manufacturing a set of 3D-printed medical appliances; providing the set of 3D-printed medical appliances to the patient; receiving feedback from the medical practitioner regarding the 3D-printed medical appliance treatment plan; modifying the dynamic 3D-printed medical appliance treatment plan generation model based on the feedback.

Abstract: A system with a saliva sampling device configured to be orally worn by a patient. The saliva sampling device is a polymer retainer or aligner. A saliva analysis engine is used to correlate one or more analytes of one or more saliva samples with one or more health attributes. A health monitoring engine updates a health profile of the patient based on the correlated health attributes.

Abstract: Devices configured for insertion into an oral cavity of a subject for delivery of an agent for a time period are described. The devices are comprised of at least two polymer shells that nest or stack to create a space or gap therebetween. The agent is placed in the gap and is released in a controlled fashion to deliver agent for the time period. Kits comprised of a device and optionally a refill of the agent are also described.

Abstract: In methods for constructing orthodontic appliances constructed from multiple layers or shells, solvents can be utilized to bond the multiple layers or shells together. Such a construction technique overcomes the aforementioned issues with utilizing preformed laminates and also allows for addition of agents between the layers when the appliance is constructed.

Abstract: A system with a saliva sampling device configured to be orally worn by a patient. The saliva sampling device is a polymer retainer or aligner. A saliva analysis engine is used to correlate one or more analytes of one or more saliva samples with one or more health attributes. A health monitoring engine updates a health profile of the patient based on the correlated health attributes.

Abstract: An orthodontic appliance is constructed from shells shaped to receive teeth. The shells can be constructed from one or more polymer materials and stacked and also varyingly affixed to one another, which can include affixing only about the edge of each shell. The orthodontic appliance can be one of a series of similar appliances for incremental orthodontic modification of teeth.

Abstract: A graphical user interface (“GUI”) is generated on the display, the GUI has a graphical depiction that simulates a translucence level of an oral appliance. The graphical depiction of the translucence level is adjustable based on a user input. A value based on the user selected translucence level is sent to an external device for determination of manufacturing parameters for the oral appliance.

Abstract: A system with a saliva sampling device configured to be orally worn by a patient. The saliva sampling device is a polymer retainer or aligner. A saliva analysis engine is used to correlate one or more analytes of one or more saliva samples with one or more health attributes. A health monitoring engine updates a health profile of the patient based on the correlated health attributes.

Abstract: An orthodontic appliance is constructed from shells shaped to receive teeth. The shells can be constructed from one or more polymer materials and stacked and also varyingly affixed to one another, which can include affixing only about the edge of each shell. The orthodontic appliance can be one of a series of similar appliances for incremental orthodontic modification of teeth.

Abstract: An orthodontic appliance shaped to receive teeth. The orthodontic appliance can be constructed from a laminate structure with an outer transparent layer and an inner translucent layer. The translucent layer can scatter light to decrease a relative degree or perceived gloss to the human eye, and hence provide a more natural appearance to the orthodontic appliance.

Abstract: An orthodontic appliance is constructed from shells shaped to receive teeth. The shells can be constructed from one or more polymer materials and stacked and also varyingly affixed to one another, which can include affixing only about the edge of each shell. The orthodontic appliance can be one of a series of similar appliances for incremental orthodontic modification of teeth.

Abstract: An orthodontic appliance is constructed from shells shaped to receive teeth. The shells can be constructed from one or more polymer materials and stacked and also varyingly affixed to one another, which can include affixing only about the edge of each shell. The orthodontic appliance can be one of a series of similar appliances for incremental orthodontic modification of teeth.

Abstract: A graphical user interface (“GUI”) is generated on the display, the GUI has a graphical depiction that simulates a translucence level of an oral appliance. The graphical depiction of the translucence level is adjustable based on a user input. A value based on the user selected translucence level is sent to an external device for determination of manufacturing parameters for the oral appliance.

Abstract: An orthodontic appliance shaped to receive teeth. The orthodontic appliance can be constructed from a laminate structure with an outer transparent layer and an inner translucent layer. The translucent layer can scatter light to decrease a relative degree or perceived gloss to the human eye, and hence provide a more natural appearance to the orthodontic appliance.