Abstract: Compositions and methods for treating and imaging vulnerable plaque and other inflammatory conditions in a patient rely on the delivery of conversion electron-emitting sources and other radionuclides to regions of exposed collagen in the vasculature or other body lumens. The conversion electron-emitting sources or other radionuclides are coupled to a collagen-binding substance and administered to the vasculature or other body lumen to permit binding for imaging and/or therapeutic purposes.
Type:
Grant
Filed:
September 25, 2006
Date of Patent:
April 18, 2017
Assignee:
SnIP Holdings, Inc.
Inventors:
Gilbert R. Gonzales, Dale DeVore, Suresh Srivastava
Abstract: The present invention discloses a method of selectively providing radiation dosimetry to a subject in need of such treatment. The radiation is applied by an implant comprising a body member and 117mSn electroplated at selected locations of the body member, emitting conversion electrons absorbed immediately adjacent selected locations while not affecting surrounding tissue outside of the immediately adjacent area.
Type:
Grant
Filed:
June 6, 2007
Date of Patent:
September 16, 2014
Assignee:
SnIP Holdings, Inc.
Inventors:
Suresh Srivastava, Gilbert R. Gonzales, Roger W. Howell, Wesley E. Bolch, Radoslav Adzic