Abstract: The invention relates to a composition comprising a first PEGylated tetanus neurotoxin (PEG-TeNT) comprising tetanus neurotoxin (TeNT) conjugated to polyethylene glycol (PEG) and a second TeNT. The invention also relates to various PEG-TeNTs. The invention also relates to a method of treating hypotonia using the composition or various PEG-TeNTs, and a kit comprising the composition or various PEG-TeNTs. In one embodiment, the hypotonia is obstructive sleep apnoea.
Type:
Grant
Filed:
July 30, 2019
Date of Patent:
August 4, 2026
Assignee:
Snoretox Pty Ltd
Inventors:
Thomas McLean, Peter Smooker, Luke Norbury, Peter Coloe, Russell Conduit, Anthony Sasse