Abstract: The invention relates to a process and an installation for destroying munitions containing toxic agent. The process comprises equipping the munitions with a pyrotechnic fragmentation device and submerging in a pool which is filled with a liquid for neutralizing the toxic agent, closing the pool with a lid so that the pool is sealed with respect to toxic emanation, and igniting the pyrotechnic device so that the munitions is fragmented and releases the toxic agent into the pool. After the fragmentation of the munitions is neutralized with the neutralizing liquid, the pool is reopened for another cycle of destruction. The advantage is of completely destroying the munitions in a single operation cycle without the risk of contamination. The invention is applicable to the destruction of munitions containing chemical or bacteriological toxic agents.