Abstract: The present invention relates to MRI contrasting agent for contrasting cancer cell which contains ultrafine nanoparticles. More particularly, the present invention is directed to a self-assembled ligand composition comprising a ligand A, which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range, MRI contrast agent for contrasting cancer cell comprising said ligand composition and MRI contrasting nanoparticles, and the methods for preparing them.
Type:
Grant
Filed:
March 27, 2015
Date of Patent:
September 19, 2017
Assignees:
SNR R&DB FOUNDATION, INSTITUTE FOR BASIC SCIENCE, THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC
Inventors:
Taeghwan Hyeon, Kun Na, Daishun Ling, Wooram Park, Byung Hyo Kim, Hyeona Yim, Kyoung Sub Kim, Michael J. Hackett, Sin-jung Park, Yang Lu, Yong Sun Jeon