Abstract: It is provided new chemical entities allowing simultaneous diagnosis and treatment of cancers. More specifically, it is provided a theranostic compound consisting of a stabilized peptide ligand (agonists and antagonists) for the kinin B1 receptors (B1R) conjugated to specific radionuclides (e.g. 64Cu) suitable for dual imaging/radiotherapy applications.
Type:
Grant
Filed:
June 23, 2016
Date of Patent:
January 4, 2022
Assignee:
SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUEE SOCPRA SCIENCES SANTE ET HUMAINES S.E.C.
Inventors:
Fernand Gobeil, Brigitte Guerin, Martin Lepage, Robert Sabbagh, David Fortin
Abstract: The present application relates to a compound of formulae (I), (II) or (III) or a pharmaceutically acceptable salt thereof, methods and uses thereof for treating disorders associated with matriptase activity.
Type:
Grant
Filed:
December 21, 2017
Date of Patent:
April 27, 2021
Assignee:
SOCIÉTÉ DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUÉE SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C.
Inventors:
Pierre-Luc Boudreault, Éloïc Colombo, Richard Leduc, Eric Marsault, Baptiste Plancq, Martin Richter
Abstract: Disclosed herein are PACE4 inhibitors, compositions comprising PACE4 inhibitors and their uses thereof for lowering PACE4 activity, reducing cell proliferation, reducing tumor growth, reducing metastasis formation, preventing and/or treating cancer. Also provided are methods for lowering PACE4 activity, reducing the proliferation of a cell, reducing tumor growth and/or treating and preventing cancer. Methods for screening PACE4 inhibitors and cell proliferation inhibitors are further provided.
Type:
Grant
Filed:
January 8, 2014
Date of Patent:
February 21, 2017
Assignee:
LA SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUEE SOCPRA-SCIENCES SANTE ET HUMAINES S.E.C.
Inventors:
Robert Day, Martin Fugére, Witold A. Neugebauer
Abstract: The present invention relates to a method of modulating splice site selection, splicing and alternative, the method comprising the step of hybridizing an oligonucleotide-protein conjugate to a target pre-mRNA molecule in a cell or cell extract, wherein the oligonucleotide-protein conjugate comprises an oligonucleotide moiety which comprises at least two distinct sequence elements: (i) a nucleic acid sequence that is complementary to a specific region upstream of the splice site in the target pre-mRNA molecule; and (ii) an extension containing a protein binding site sequence element for covalently binding a protein; wherein the protein moiety comprises a protein capable of modulating splicing of the splice site upon binding with the protein binding site.
Type:
Grant
Filed:
November 14, 2008
Date of Patent:
October 1, 2013
Assignee:
La Societe de Commercialisation des Produits de la Recherche Appliquee Socpra-Sciences Sante et Humaines S.E.C.
Abstract: A blood counting device comprises a capillary conduit for drawing from a subject in which a radiotracer has previously been injected a quantity of blood in the micro-liter range to produce in the capillary conduit a flow of blood from which beta radiation is emitted. At least one direct beta radiation detector is placed closely adjacent to the capillary conduit. The direct beta radiation detector consists of a semiconductor photodiode which detects the beta radiation from the flow of blood when directly hit by this beta radiation.
Type:
Grant
Filed:
March 17, 2006
Date of Patent:
September 11, 2012
Assignee:
Société de Commercialisation des Produits de la Recherche Appliquée-Socpra Sciences Sante et Humaines S.E.C.
Inventors:
Laurence Convert, Jules Cadorette, David Lapointe, Roger Lecomte
Abstract: An iterative image reconstruction method used with an imaging system that generates projection data, the method comprises: collecting the projection data; choosing a polar or cylindrical image definition comprising a polar or cylindrical grid representation and a number of basis functions positioned according to the polar or cylindrical grid so that the number of basis functions at different radius positions of the polar or cylindrical image grid is a factor of a number of in-plane symmetries between lines of response along which the projection data are measured by the imaging system; obtaining a system probability matrix that relates each of the projection data to each basis function of the polar or cylindrical image definition; restructuring the system probability matrix into a block circulant matrix and converting the system probability matrix in the Fourier domain; storing the projection data into a measurement data vector; providing an initial polar or cylindrical image estimate; for each iteration; reca
Type:
Grant
Filed:
May 9, 2008
Date of Patent:
July 19, 2011
Assignee:
Société De Commercialisation Des Produits De La Recherche Appliquée - Socpra Sciences Santé Et Humaines, S.E.C.
Inventors:
Jean-Daniel Leroux, Rèjean Fontaine, Roger Lecomte, Vitali Selivanov
Abstract: A digital method and system allowing crystal identification in radiation detector machines is described. The crystal identification is based on recognition of radiation detector signal shape through discrimination of detector signal's dynamic characteristics. The digital method is based on recursive and non-recursive algorithms, such as adaptive filtering combined or not with quantization methods. These digital algorithms, commonly used in other engineering applications, were modified and tailored for radiation detection. Although the method was specially designed for crystal identification measurement, which is exemplified here, it can effectively recognize the detector signal shape in any radiation detection context.
Type:
Grant
Filed:
August 18, 2006
Date of Patent:
September 7, 2010
Assignee:
Societe De Commercialisation Des Produits De La Recherche Appliquee- Socpra Sciences Sante Et Humaines, S.E.C.
Inventors:
Jean-Baptiste Michaud, Hicham Semmaoui, Nicolas Viscogliosi, Rejean Fontaine, Roger Lecomte