Abstract: It is described an endoscope to perform surgeries preferably by perforation in translumenal organs in internal organs, comprising an insertion tube (10?) having a distal end (12?) and at least two working channels, one working channel having a smaller diameter (20?) and one working channel having a larger diameter (30?), the working channels (20?,30?) being capable of receiving surgical tools, the endoscope comprising at least two command cables (9?) operatively associated with the working channel of smaller diameter (20?) and at least two command cables (9?) operatively associated with the working channel of larger diameter (30?), the command cables (9?) being capable of allowing the surgical tool, arranged on any of the working channels (20?,30?), to move in any direction, regardless of the movement of the distal end (12?) of the insertion tube (10?).

Abstract: It is described an endoscope to perform surgeries preferably by perforation in translumenal organs in internal organs, comprising an insertion tube (10?) having a distal end (12?) and at least two working channels, one working channel having a smaller diameter (20?) and one working channel having a larger diameter (30?), the working channels (20?,30?) being capable of receiving surgical tools, the endoscope comprising at least two command cables (9?) operatively associated with the working channel of smaller diameter (20?) and at least two command cables (9?) operatively associated with the working channel of larger diameter (30?), the command cables (9?) being capable of allowing the surgical tool, arranged on any of the working channels (20?,30?), to move in any direction, regardless of the movement of the distal end (12?) of the insertion tube (10?).

Abstract: It is described an endoscope to perform surgeries preferably by perforation in translumenal organs in internal organs, comprising an insertion tube (10?) having a distal end (12?) and at least two working channels, one working channel having a smaller diameter (20?) and one working channel having a larger diameter (30?), the working channels (20?,30?) being capable of receiving surgical tools, the endoscope comprising at least two command cables (9?) operatively associated with the working channel of smaller diameter (20?) and at least two command cables (9?) operatively associated with the working channel of larger diameter (30?), the command cables (9?) being capable of allowing the surgical tool, arranged on any of the working channels (20?,30?), to move in any direction, regardless of the movement of the distal end (12?) of the insertion tube (10?).

Abstract: The present invention refers to a pharmaceutical composition that includes an active ingredient, such as a peptide, which acts as an antagonist and/or inverse agonist of a G protein-coupled receptor and pharmaceutically acceptable vehicle. The pharmaceutical composition may be used for the treatment of obesity and the prevention of and the treatment of diabetes.