Abstract: Procedure for the preparation of a concentrate of prothrombinogenic compound.This procedure, in which, starting from a source of prothrombinogenic compound, an adsorption is followed by an elution, is characterized by the fact that a source of prothrombinogenic compound and a source of antithrombin III (or AT III) is placed in contact with an adsorbing agent capable of adsorbing both the prothrombinogenic compound and antithrombin III, and that the foregoing occurs in the presence of heparin, at least during the elution stage, and that elution is carried out with an elution agent capable of eluting the prothrombinogenic compound, the AT III and heparin at the same time.Application of the product obtained, notably to the treatment of blood coagulation difficulties.
Type:
Grant
Filed:
March 17, 1983
Date of Patent:
August 14, 1984
Assignee:
Societe Anonyme dite: Institut Merieux
Inventors:
Maryse Chanas, Jacques Liautaud, Jean Pla, Edward Shanbrom
Abstract: The invention is concerned with a medium onto which is fixed a ganglioside or ganglioside derivative having an affinity for the toxins produced by the bacteria responsible for diarrheas and in particular for the cholera toxin.