Abstract: The invention relates to new propenone oxime ethers, a method of preparing them and pharmaceutical compositions containing them.Said new propenone oxime ethers have the formula ##STR1## in which--Ar and Ar' each independentlyl denotes a phenyl group non-substituted, mono or polysubstituted, a 9-anthryl group or a naphthyl group, a pyridyl, thienyl or furyl group;R.sub.1 R.sub.2 each independently denotes hydrogen, a C.sub.1 -C.sub.4 alkyl group or together with the N-atom to which they are bonded a 1-pyrrolidinyl, piperidino, morpholino or 1-piperazinyl group;M=H, Cl, Br or a C.sub.1 -C.sub.6 alkyl groupn=2 or 3.The invention also deals with the salts of compounds of formula (I). Said compounds have good activity in the anti platelet-clotting tests and are also antagonists of the 5HT.sub.2 receptors.
Type:
Grant
Filed:
December 1, 1989
Date of Patent:
November 24, 1992
Assignee:
Societe Anonyme: Sanofi
Inventors:
Christian Congy, Patrick Gueule, Bernard Labeeuw, Murielle Rinaldi
Abstract: The invention relates to novel tricyclic derivatives which are agonists of cholinergic receptors.These derivatives have the formula ##STR1## in which X=O, S, --OCH.sub.2 -- or --SCH.sub.2 --; R.sub.1 =H or halogen; and R.sub.2 = ##STR2## in which Alk is an alkylene group and R.sub.3, an R.sub.4, which are identical or different, are hydrogen or a lower alkyl group, or R.sub.3 and R.sub.4, with the nitrogen atom to which they are bonded, form a 5- or 6-membered cyclic amino group optionally containing a second heteroatom; or R.sub.2 is a group ##STR3## where R.sub.5 =C.sub.1 -C.sub.4 -alkyl. Application: agonists of cholinergic receptors.
Type:
Grant
Filed:
December 23, 1988
Date of Patent:
January 8, 1991
Assignee:
Societe Anonyme: SANOFI
Inventors:
Camille G. Wermuth, Paul Worms, Jean-Jacques Bourguignon, Roger Brodin
Abstract: A powdered composition for dental impressions, comprising a water-soluble alginate, a gelling agent, a gelling regulator and fillers coated with a hydrolyzed gelatin.
Abstract: The invention relates to novel tricyclic derivatives which are agonists of cholinergic receptors and to drugs containing them.These derivatives have the following formula: ##STR1## in which: X represents a group (CH.sub.2).sub.n, n representing an integer equal to 2, 3 or 4, or alternatively a vinylene group or a methylvinylene group;R.sub.1 and R.sub.2, considered independently, represent hydrogen or a substituent occupying one of the free positions of the benzene ring and selected from the group comprising halogens, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a thiol group, a nitro group and an optionally substituted amino group;Y represents oxygen, sulfur or a group --NH--; andR.sub.3 is an amino groupApplication: agonists of the cholinergic receptors.
Type:
Grant
Filed:
January 25, 1990
Date of Patent:
December 11, 1990
Assignee:
Societe Anonyme: Sanofi
Inventors:
Kathleen Biziere, Camille G. Wermuth, Paul Worms, Jean-Jacques Bourguignon
Abstract: The present invention relates to the use of ademetionine or one of its salts for the preparation of pharmaceutical or cosmetic compositions for counteracting ageing of the skin.It further relates to the said cosmetic compositions.
Type:
Grant
Filed:
November 25, 1988
Date of Patent:
September 11, 1990
Assignee:
Societe Anonyme: SANOFI
Inventors:
Gerard Le Fur, Michele Bousquet, Emilio Crisafulli, Michel Sabadie
Abstract: The invention relates to a microbiological process for the preparation of a protein by culturing a mutant bacterial strain.This process consists in using a bacterial strain carrying a mutation which limits, or even suppresses, the expression of the operons whose transcription depends on the fixation of the cAMP-CRP complex, a DNA sequence coding for a protein precursor having been introduced into the said bacterial strain.
Type:
Grant
Filed:
April 9, 1987
Date of Patent:
July 31, 1990
Assignee:
Societe Anonyme: Sanofi
Inventors:
Richard Legoux, Pascal Leplatois, Evelyne L. Joseph, Brigitte Niaudet, Willem Roskam
Abstract: The 3-aminoazetidine, its salts, new intermediates of formula ##STR1## wherein X' represents hydrogen or a protecting group and both X" represent hydrogen or, together with the nitrogen atom, a phthalimido group, X' not and both X" being hydrogen at the same time; a process for the preparation of the 3-aminoazetidine, starting from a 1-protected 3-sulfonyloxyazetidine by reaction with the potassium phthalimide and transformation of the above mentioned intermediates.
Abstract: The present invention relates to a process for the stereo-specific synthesis of indole derivatives of formula: ##STR1## which consists in using 3-tosyloxy-1,2-O-isopropylidenepropane-1,2-diol (II) in an optically pure form in order to introduce the asymetric carbon C* of compound (I). Compound (II) is condensed with a suitable primary amine in order to prepare an oxazolidinone and condensation with a suitable phenol, and the oxazolidinone ring is then opened to form an indole compound (I).
Type:
Grant
Filed:
June 29, 1987
Date of Patent:
February 21, 1989
Assignee:
Societe Anonyme: Sanofi
Inventors:
Jean Wagnon, Claude Plouzane, Bernard Tonnerre, Dino Nisato
Abstract: The invention relates to a process for the preparaton of compounds of the formula I by reacting an alkali metal alcoholate with a compound of the formula II in the presence of an aliphatic ester such as methyl formate, and then condensing guanidine with the resulting compound of the formula III.The compound of the formula II can be prepared by reacting the corresponding benzaldehyde with acrylonitrile in the presence of diazabicyclo-2,2,2,-octane.
Type:
Grant
Filed:
July 31, 1987
Date of Patent:
December 6, 1988
Assignee:
Societe Anonyme: Sanofi Pharma S.A. - Succursale de Carouge