Abstract: The invention relates to a process for the preparaton of compounds of the formula I by reacting an alkali metal alcoholate with a compound of the formula II in the presence of an aliphatic ester such as methyl formate, and then condensing guanidine with the resulting compound of the formula III.The compound of the formula II can be prepared by reacting the corresponding benzaldehyde with acrylonitrile in the presence of diazabicyclo-2,2,2,-octane.
Type:
Grant
Filed:
July 31, 1987
Date of Patent:
December 6, 1988
Assignee:
Societe Anonyme: Sanofi Pharma S.A. - Succursale de Carouge